2008
DOI: 10.1063/1.3043805
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Vortex filament dynamics in computational models of ventricular fibrillation in the heart

Abstract: In three-dimensional cardiac tissue, the re-entrant waves that sustain ventricular fibrillation rotate around a line of phase singularity or vortex filament. The aim of this study was to investigate how the behavior of these vortex filaments is influenced by membrane kinetics, initial conditions, and tissue geometry in computational models of excitable tissue. A monodomain model of cardiac tissue was used, with kinetics described by a three-variable simplified ionic model (3V-SIM). Two versions of 3V-SIM were … Show more

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Cited by 26 publications
(42 citation statements)
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“…Monodomain, not bidomain, models of cardiac electrical activity are almost exclusively used in computational investigations of cardiac arrhymia mechanisms [13], [14], [15], [16], [17] due to the relatively large load required to solve the bidomain problem over large-scale models [18]. The presented augmented monodomain equivalent bidomain modelling approach facilitates investigation of the consequences of the bath-induced wavefront curvature upon arrhythmic activity during very long duration simulations due to its much faster solution time, shown here to be approximately 7 times faster than the BDM model, on the particular set-up used here.…”
Section: Discussionmentioning
confidence: 99%
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“…Monodomain, not bidomain, models of cardiac electrical activity are almost exclusively used in computational investigations of cardiac arrhymia mechanisms [13], [14], [15], [16], [17] due to the relatively large load required to solve the bidomain problem over large-scale models [18]. The presented augmented monodomain equivalent bidomain modelling approach facilitates investigation of the consequences of the bath-induced wavefront curvature upon arrhythmic activity during very long duration simulations due to its much faster solution time, shown here to be approximately 7 times faster than the BDM model, on the particular set-up used here.…”
Section: Discussionmentioning
confidence: 99%
“…In spite of the knowledge that a surrounding conducting media influences wavefront morphology [2], [8], [9], the monodomain approximation (where intra- and extracellular domains are assumed equally anisotropic), which cannot explicitly represent a bath, has been widely used to simulate electrical activity during propagation and investigations into cardiac arrhythmia mechanisms [13], [14], [15], [16], [17]. As arrhythmia studies generally require simulation over substantial periods of time (> 1s for example [16], [17]), performing full bidomain simulations on high-resolution whole ventricular models can represent a significant computational cost [18], thus favouring the monodomain approach (~ 10 times faster than bidomain [18]).…”
Section: Introductionmentioning
confidence: 99%
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“…Another often considered possibility is scroll turbulence due to purely 2D mechanisms which make spiral waves unstable, e.g. [Panfilov and Holden, 1990] and which of course reveal themselves in 3D as well [Clayton and Holden, 2003, Clayton et al, 2006, Clayton, 2008, Reid et al, 2011.…”
Section: Scroll Wave Turbulencementioning
confidence: 99%
“…Clayton and co-workers [12] examined the evolution of VF within the 3D volume of the rabbit and canine ventricles by quantifying the dynamics of the scroll-wave filaments, the organizing centers of reentry. These studies determined the number of filaments and their lifetimes, and classified their shapes, which depend on the location of the filaments within the ventricles.…”
Section: Models Of Ventricular Arrhythmia Mechanisms In the Normal Heartmentioning
confidence: 99%