Voxel-based analysis of multiple-system atrophy of cerebellar type: complementary results by combining voxel-based morphometry and voxel-based relaxometry

Specht, Karsten; Minnerop, Martina; Müller-Hübenthal, Jonas; Klockgether, Thomas

doi:10.1016/j.neuroimage.2004.11.022

Cited by 57 publications

(46 citation statements)

References 28 publications

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“…In accordance to the VBM analysis in MSA-C, which showed reductions in gray and white matter in the cerebellum and brainstem, VBR analysis of the same patients revealed reduction in relaxation rate R2 in the same regions reflecting infratentorial brain atrophy [80] . In addition, R2 was increased in the putamen, a region in which VBM did not show abnormalities, thus suggesting that the combination of VBR and VBM may provide convergent and complementary information about the brain morphology of MSA-C [80] . The observed R2 increase in the putamen corresponds to the hypointensity observed on conventional T 2 -weighted images probably due to increased iron content [20] .…”

Section: Roi-based Mr Planimetry and Volumetrysupporting

confidence: 74%

“…In contrast to operator-dependent segmentation techniques including ROI selection, VBM permits an operator-independent and automated detection of significant differences in different tissue types of the whole brain involving voxel-wise statistical analysis of preprocessed structural MR images with the aid of statistical parametric mapping [78] . Voxel-based relaxometry (VBR) is a technique based on voxel-by-voxel calculation of whole brain T 2 relaxation rate (R2) maps derived from multi-echo T 2 -weighted images to assess signal abnormalities [79,80] . In principle, decreased R2 indicates raised water content (consistent with increased T 2 ) and can therefore provide a measure of tissue atrophy.…”

Section: Quantitative Assessment Of Regional Cerebral Atrophymentioning

confidence: 99%

“…VBM has also been used to investigate the progression of cortical and subcortical atrophy patterns in MSA-P compared with PD, and revealed early degeneration of the basal ganglia followed by later onset cortical atrophy [99] . Also VBR has recently been used to study brain morphology in MSA-C versus MSA-P and healthy volunteers [79,80] . In accordance to the VBM analysis in MSA-C, which showed reductions in gray and white matter in the cerebellum and brainstem, VBR analysis of the same patients revealed reduction in relaxation rate R2 in the same regions reflecting infratentorial brain atrophy [80] .…”

Section: Roi-based Mr Planimetry and Volumetrymentioning

confidence: 99%

“…Also VBR has recently been used to study brain morphology in MSA-C versus MSA-P and healthy volunteers [79,80] . In accordance to the VBM analysis in MSA-C, which showed reductions in gray and white matter in the cerebellum and brainstem, VBR analysis of the same patients revealed reduction in relaxation rate R2 in the same regions reflecting infratentorial brain atrophy [80] . In addition, R2 was increased in the putamen, a region in which VBM did not show abnormalities, thus suggesting that the combination of VBR and VBM may provide convergent and complementary information about the brain morphology of MSA-C [80] .…”

Section: Roi-based Mr Planimetry and Volumetrymentioning

confidence: 99%

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Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

et al. 2010

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The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology, even for movement disorder specialists. Despite published consensus operational criteria for the diagnosis of Parkinson’s disease (PD) and the various atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy, multiple system atrophy, and corticobasal syndrome, the clinical separation of APDs from PD carries a high rate of misdiagnosis. However, an early differentiation between APD and PD, each characterized by a largely different natural history, is crucial for determining the prognosis and choosing a treatment strategy. Despite limitations, the different modern magnetic resonance (MR) techniques have undoubtedly added to the differential diagnosis of neurodegenerative parkinsonism. Conventional MRI with visual assessment of T₂- and T₁-weighted imaging as well as various advanced MRI techniques offer objective measures and may therefore be useful tools in the diagnostic workup of PD and APDs. In clinical practice, conventional MRI is a well-established method for the exclusion of symptomatic parkinsonism due to other pathologies such as tumors, cerebral ischemia or inflammatory diseases. Furthermore, over the past two decades, advances in MR techniques have enabled to quantitatively illustrate abnormalities in the basal ganglia and infratentorial structures in APDs by methods such as magnetic resonance volumetry, diffusion-weighted imaging, magnetization transfer imaging and proton magnetic resonance spectroscopy. This article aims to review research findings on the value of MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders.

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Section: Roi-based Mr Planimetry and Volumetrysupporting

confidence: 74%

Section: Quantitative Assessment Of Regional Cerebral Atrophymentioning

confidence: 99%

Section: Roi-based Mr Planimetry and Volumetrymentioning

confidence: 99%

Section: Roi-based Mr Planimetry and Volumetrymentioning

confidence: 99%

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Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

et al. 2010

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“…This was in accordance with the VBM analysis, which showed reductions of gray and white matter in the same regions. In addition, R2 was increased in the putamen, a region in which VBM did not show abnormalities, thus suggesting that the combination of VBR and VBM may provide convergent and complimentary information about the brain morphology of MSA-C. 92 Using VBM and VBR, direct comparison of MSA-C and MSA-P showed differences only in infratentorial brain regions where structural abnormalities were more pronounced in MSA-C than in MSA-P. In MSA-C, there was a stronger reduction of gray matter in the basal parts of the cerebellum, of white matter in the brainstem, and of the relaxation rate R2 in the cerebellum and brainstem.…”

Section: S712mentioning

confidence: 97%

Potential of advanced MR imaging techniques in the differential diagnosis of parkinsonism

et al. 2009

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The clinical differentiation of parkinsonian syndromes remains challenging not only for neurologists but also for movement disorder specialists. Conventional magnetic resonance imaging (cMRI) with the visual assessment of T2- and T1-weighted imaging as well as different advanced MRI techniques offer objective measures, which may be a useful tool in the diagnostic work-up of Parkinson's disease and atypical parkinsonian disorders (APDs). In clinical practice, cMRI is a well-established method for the exclusion of symptomatic parkinsonism due to other pathologies. Over the past two decades, abnormalities in the basal ganglia and infratentorial structures have been shown especially in APDs not only by cMRI but also by different advanced MRI techniques, including methods to assess regional cerebral atrophy quantitatively such as magnetic resonance volumetry, proton magnetic resonance spectroscopy, diffusion-weighted imaging, and magnetization transfer imaging. This article aims to review recent research findings on the role of advanced MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders.

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Disentangling the prefrontal network for rule selection by means of a non‐verbal variant of the Wisconsin Card Sorting Test

Specht

Lie

Shah

et al. 2008

Human Brain Mapping

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This study disentangles the prefrontal network underlying executive functions involved in the Wisconsin Card Sorting Test (WCST). During the WCST, subjects have to perform two key processes: first, they have to derive the correct sorting rule for each trial by trial-and-error, and, second, they have to detect when this sorting rule is changed by the investigator. Both cognitive processes constitute key components of the executive system, which is subserved by the prefrontal cortex. For the current fMRI experiment, we developed a non-verbal variant of the WCST. Subjects were instructed either to respond according to a given sorting rule or to detect the correct sorting rule, like in the original version of the WCST. Data were obtained from 14 healthy male volunteers and analysed using SPM and a random effects model. All conditions activated a fronto-parietal network, which was generally more active when subjects had to search for the correct sorting rule than when the rule was announced beforehand. Significant differences between these two conditions were seen in the dorsolateral prefrontal cortex (PFC) and the parietal lobe. In addition, the data provided new evidence for the assumption of differentiated roles of the left and right prefrontal cortex. Although the right PFC showed a general involvement in response selection and the execution of goal directed responses, based on given rules, the left PFC was only activated when inductive reasoning and feedback integration was required.

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Voxel-based analysis of multiple-system atrophy of cerebellar type: complementary results by combining voxel-based morphometry and voxel-based relaxometry

Cited by 57 publications

References 28 publications

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

Potential of advanced MR imaging techniques in the differential diagnosis of parkinsonism

Disentangling the prefrontal network for rule selection by means of a non‐verbal variant of the Wisconsin Card Sorting Test

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