Voxel-based assessment of spinal tap test-induced regional cerebral blood flow changes in normal pressure hydrocephalus

Abstract

According to SPM analysis, gait improvement at the spinal tap test in patients with NPH syndrome is associated with an rCBF increase localized in the bilateral dorsolateral frontal and left mesiotemporal cortex.

Correlation of right frontal hypoperfusion and urinary dysfunction in iNPH: A SPECT study

“…The wider activation associated with DO might reflect simultaneous pelvic floor contraction against DO in order to maintain urinary continence 35. Previous studies have shown hypoperfusion in the frontal lobe in NPH patients using PET,13–15 SPECT,16–18 and perfusion‐weighted MRI,19 most of which are bilateral. However, using bladder function‐related perfusion analysis in the present study, the right frontal cortex showed deactivation more than the left.…”

“…Recent functional neuroimaging, that is, positron emission tomography (PET), in normal volunteers has shown that the anterior cingulate, prefrontal cortex and insula are activated in response to bladder filling as compared with an empty bladder 10–12. Although NPH is a diffuse brain disease with dilated ventricles, hypoperfusion in the frontal lobe has been documented in NPH patients using PET,13–15 single‐photon emission computed tomography (SPECT),16–18 and perfusion‐weighted magnetic resonance imaging (MRI) 19. Therefore, it is possible that the frontal lobe is the anatomical substrate for the development of neurogenic urinary incontinence in NPH.…”

Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus Guidelines From the Guidelines Committee of Idiopathic Normal Pressure Hydrocephalus, the Japanese Society of Normal Pressure Hydrocephalus

“…70,114) A voxel-based analysis study reported a significant CBF increase in the bilateral dorsolateral frontal and left mesiotemporal cortices after the tap test. 25) No increase of CBF after the tap test was also reported. 54B) The involvement of autoregulatory impairment is still controversial.…”

Development of involuntary movements after ventriculoperitoneal shunting for normal pressure hydrocephalus in a patient with chronic-phase thalamic haemorrhage

“…Dumarey et al [10] reported that gait improvement after STT in patients with NPH is associated with a bilateral regional CBF increase in the dorsolateral frontal cortex and an increase in the left mesial temporal cortex. This patient could walk more rapidly and smoothly after STT, because of partial alleviation of NPH.…”