Voxel based comparison of glucose metabolism in the differential diagnosis of the multiple system atrophy using statistical parametric mapping

Juh, R; Pae, Chi‐Un; Lee, Chang-Uk; Yang, Dong-Won; Chung, Yong‐An; Suh, T; Choe, Bo-Young

doi:10.1016/j.neures.2005.03.010

Cited by 41 publications

(28 citation statements)

References 26 publications

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“…22,23 When comparing all nondemented PD patients to the controls, the results of our study were consistent with those of the previous studies. However, when we subclassified the subjects into PDMCI and PDNC, crucial differences emerged between the two groups.…”

Section: Discussionsupporting

confidence: 91%

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

et al. 2009

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There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo-parieto-occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia.

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Section: Discussionsupporting

confidence: 91%

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

et al. 2009

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“…These results are in agreement with previous studies that demonstrated significant glucose hypometabolism of the striatum, pons, and cerebellum in MSA patients compared with controls and patients with PD. [21][22][23][24][25][26][27][28] The importance of our results is that the time interval between clinical symptom onset of MSA and 18 F-FDG PET was less than 28 months. Therefore, 18 F-FDG PET may be of differential diagnostic value for early stages of MSA-P and MSA-C, in addition to differentiating MSA from PD.…”

Section: Discussionmentioning

confidence: 72%

Comparison of brain MRI and ¹⁸F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease

et al. 2007

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To investigate the diagnostic value of brain magnetic resonance image (MRI) and (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty-five patients with MSA (23 MSA-P and 12 MSA-C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA-P, MSA-C, and PD patients were 80% for visual MRI analysis, 88.5% for visual (18)F-FDG PET analysis, and 84.3% for SPM-supported analysis of (18)F-FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of (18)F-FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and (18)F-FDG PET are diagnostically useful in differentiating MSA (MSA-P and MSA-C) from PD, and indicate that (18)F-FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings.

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“…Likewise, imaging results in patients with clinically diagnosed PSP and CBD may be very similar. In direct comparison of clinically defined patient groups, PSP patients showed a lower metabolism in the midbrain, thalamus, and cingulate gyrus, whereas CBD patients revealed a more pronounced and asymmetric hypometabolism in the parietal and sensorimotor cortex and striatum (51)(52)(53)(54). According to recent studies with support by postmortem data, parietal involvement and the asymmetry of the aforementioned frontoparietal hypometabolism appear to be most characteristic of CBD (45,55).…”

Section: Disease-specific Patterns Of Regional Glucose Metabolismmentioning

confidence: 90%

¹⁸F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment

et al. 2017

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Learning Objectives: On successful completion of this activity, participants should be able to (1) describe the clinical demand and rationale for differential diagnosis in parkinsonism, (2) recognize and differentiate the disease-specific patterns of regional glucose metabolism associated with Parkinson disease and the different atypical parkinsonian syndromes, and (3) identify regional metabolic changes that predict cognitive decline in Parkinson disease.Financial Disclosure: Dr. Meyer receives support from GE and Piramal for a research study outside the present topic. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA category 1 credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, SAM, and other credit types, participants can access this activity through the SNMMI website (http://www.snmmilearningcenter.org) through December 2020.Accurate differential diagnosis of parkinsonism is of paramount therapeutic and prognostic importance. In addition, with the development of invasive therapies and novel disease-specific therapies, strategies for patient enrichment in trial populations are of growing importance. Imaging disease-specific patterns of regional glucose metabolism with PET and 18 F-FDG allows for a highly accurate distinction between Parkinson disease (PD) and atypical parkinsonian syndromes, including multiple-system atrophy, progressive supranuclear palsy, and corticobasal degeneration. On the basis of a preliminary metaanalysis of currently available studies with inclusion of multiple disease groups, we estimated that the diagnostic sensitivity and specificity for visual PET readings supported by voxel-based statistical analyses for diagnosis of atypical parkinsonian syndromes are 91.4% and 90.6%, respectively. The diagnostic specificity of 18 F-FDG PET for diagnosing multiple-system atrophy, progressive supranuclear palsy, and corticobasal degeneration was consistently shown to be high (.90%), whereas sensitivity was more variable (.75%). It is increasingly acknowledged that cognitive impairment represents a major challenge in PD, with mild cognitive impairment being a prodromal stage of PD with dementia (PDD). In line with clinical and neuropsychologic studies, recent PET studies demonstrated that posterior cortical dysfunction in nondemented PD patients precedes cognitive decline and the development of PDD by several years. Taken together, the current literature underscores the utility of 18 F-FDG PET for diagnostic evaluation of parkinsonism and the promising role of 18 F-FDG PET for assessment and risk stratification of cognitive impairment in PD.

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Voxel based comparison of glucose metabolism in the differential diagnosis of the multiple system atrophy using statistical parametric mapping

Cited by 41 publications

References 26 publications

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

Comparison of brain MRI and ¹⁸F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease

¹⁸F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment

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Voxel based comparison of glucose metabolism in the differential diagnosis of the multiple system atrophy using statistical parametric mapping

Cited by 41 publications

References 26 publications

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

Comparison of brain MRI and 18F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease

18F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment

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Comparison of brain MRI and ¹⁸F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease

¹⁸F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment