Voxel-based morphometry in the detection of dysplasia and neoplasia in childhood epilepsy: Limitations of grey matter analysis

Bruggemann, Jason; Wilke, Marko; Som, Seu; Bye, Ann; Bleasel, Andrew; Lawson, John A.

doi:10.1016/j.jocn.2008.08.025

Cited by 25 publications

(22 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…VBM is a fully automated image processing framework able to identify regional density differences in brain tissue at the level of a voxel. Several groups 42,[45][46][47][48][49][50] applied VBM in our field, suggesting this technique may identify subtle lesions 48 .…”

Section: Discussionmentioning

confidence: 96%

MRI Findings in Low Grade Tumours Associated with Focal Cortical Dysplasia

et al. 2012

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is mandatory to identify the epileptogenic zone in refractory temporal lobe epilepsy (TLE). The correct identification of lesions is essential to obtain good post-surgery seizure control. Low grade tumours (LGT) and focal cortical dysplasia (FCD) are common findings in symptomatic TLE, and frequently coexist. The aim of this study was to identify the MRI characteristics in the diagnosis of FCD associated with LGT. We analyzed 24 subjects with TLE who underwent tailored surgery. They all had LGTs. Two expert neuroradiologists analyzed the imaging data and compared them with histological results, hypothesizing the causes of diagnostic errors in the identification of FCD. We selected three exemplary cases to report the most important causes of errors. In the diagnosis of FCD we reported false positives and false negatives due to different causes. An incomplete MRI protocol, the large dimensions of the tumour, infiltration and related oedema were the most important factors limiting MRI accuracy. MRI can be limited by an incomplete protocol. In addition, the presence of an LGT may limit the neuroradiological diagnosis of FCD in the temporal lobe. Advanced MRI techniques could help reveal subtle lesions that eluded a previous imaging inspection.

show abstract

Section: Discussionmentioning

confidence: 96%

MRI Findings in Low Grade Tumours Associated with Focal Cortical Dysplasia

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Computer-assisted methods, such as voxel-based morphometry (VBM) 18 , surface reconstructions and segmentation techniques 19,20 may aid in detection of subtle lesions, but these automatic approaches still need to surpass intrinsic inaccuracies and remain to be proven helpful to the unassisted human eye in prospective studies 16,18 . Nevertheless, clinical information is still absolutely important in guiding the intensive and time-consuming visual search that is required in the evaluation of milimetric volume acquisitions with multiplanar reformats.…”

Section: Modern Neuroimaging Techniquesmentioning

confidence: 99%

Malformations of cortical development: current concepts and advanced neuroimaging review

Andrade

Leite

2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Malformations of cortical development (MCD) result from disruptions in the complex process of the human brain cortex formation and are highly associated to severe epilepsy, neurodevelopmental delay and motor dysfunction. Nowadays, magnetic resonance imaging (MRI) is the cornerstone of the work-up of patients with epilepsy and modern advanced imaging techniques have improved not only our ability to detect and characterize cortical malformations, but also in identifying associated functional abnormalities that are far beyond the structural visualized lesions. Herein, we address the most currently used classifications of MCD and make a concise review of the embryological process of cortical development. Our main goal is to summarize recent advances and new trends in diagnostic imaging techniques concerning MCD. Thereafter, follows a brief discussion of specific disorders and their radiological features. Key words: malformations of cortical development, epilepsy, magnetic resonance imaging, diagnostic imaging.Malformações do desenvolvimento cortical: conceitos atuais e revisão de neuro imagem avançada RESUMO As malformações do desenvolvimento cortical (MDC) resultam de distúrbios no complexo processo do desenvolvimento do córtex cerebral humano e estão comumente associadas a epilepsia severa e disfunções neuropsicomotoras. Atualmente, as imagens por ressonância magnética (RM) são a pedra angular no manejo de pacientes com epilepsia e modernas técnicas avançadas de imagem melhoraram não só a nossa capacidade de detectar e caracterizar as malformações corticais, mas também levaram ao reconhecimento de anomalias funcionais associadas que estão muito além das lesões estruturais visibilizadas. Abordaremos as classificações mais utilizadas de MDC e revisaremos a embriologia do desenvolvimento cortical. Nosso principal objetivo é destacar os avanços recentes e as novas tendências em técnicas de diagnóstico por imagens relacionadas às MDC. Em seguida, faremos uma breve discussão sobre alguns transtornos específicos e suas características radiológicas. Palavras-chave: malformações do desenvolvimento cortical, epilepsia, imagem por ressonância magnética, diagnóstico por imagem.

show abstract

“…As these lesions are subtle and associated with abnormal cortical thickness, indistinctness of transition between GM/WM, abnormal sulcal pattern and hyperintense signal on T1-weighted images [56], it was expected that lesions should be revealed by morphometric study. Unfortunately, the results showed some limitations of the method in detecting subtle lesions [57,58]; most likely because the location of abnormalities in FCD varies among patients, thus averaging out the abnormalities in group comparisons, and because of the limitation of VBM in analyzing single individuals against a control group. Nevertheless, a few studies showed high sensitivity in the detection of GM excess corresponding to visually detected FCD [6,16], while others concluded that the sensitivity of the method was insufficient for clinical application [57,59].…”

Section: Extratemporal Epilepsy and Vbmmentioning

confidence: 99%

“…Nevertheless, a few studies showed high sensitivity in the detection of GM excess corresponding to visually detected FCD [6,16], while others concluded that the sensitivity of the method was insufficient for clinical application [57,59]. Technical aspects in the processing of images may influence the rate of detection, as ana lysis of GM concentration (instead of GM volume) produced higher rates of lesion detection, as well as the combination of GM/WM maps [59], and the application of smaller kernels, such as 6 mm, was associated with an increase in false-positive results [58].…”

Section: Extratemporal Epilepsy and Vbmmentioning

confidence: 99%

Voxel-based morphometry and epilepsy

Yasuda

Betting

Cendes

2010

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

Voxel-based morphometry is an automated technique for MRI analyses, developed to study differences in brain morphology and frequently used to study patients with diverse disorders. In epilepsy, it has been used to investigate areas with reduction or increase of gray and white matter, in different syndromes (i.e., temporal lobe epilepsy, focal cortical dysplasia and generalized epilepsies). In temporal lobe epilepsy, voxel-based morphometry showed gray/white matter atrophy extending beyond the atrophic hippocampus. These widespread abnormalities have been associated with seizure frequency, epilepsy duration, incidence of precipitating factors, cognitive dysfunction and surgical outcome. In generalized epilepsies, gray matter abnormalities were identified mainly in the thalamus and frontal cortex, reinforcing the role of the thalamocortical network in the mechanisms of generalized seizures.

show abstract

Voxel-based morphometry in the detection of dysplasia and neoplasia in childhood epilepsy: Limitations of grey matter analysis

Cited by 25 publications

References 38 publications

MRI Findings in Low Grade Tumours Associated with Focal Cortical Dysplasia

MRI Findings in Low Grade Tumours Associated with Focal Cortical Dysplasia

Malformations of cortical development: current concepts and advanced neuroimaging review

Voxel-based morphometry and epilepsy

Contact Info

Product

Resources

About