Voxel-Based Quantitative Analysis of Brain Images From 18F-FDG PET With a Block-Matching Algorithm for Spatial Normalization

Person, Christophe; Louis-Dorr, Valérie; Poussier, Sylvain; Commowick, Olivier; Malandain, Grégoire; Maillard, Louis; Gillet, Nicolas; Roch, Véronique; Karcher, Gilles; Marie, Pierre-Yves

doi:10.1097/rlu.0b013e3182443b2d

Cited by 9 publications

(1 citation statement)

References 14 publications

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“…SPM requires spatial normalization to align all images to a standard anatomic model (the template), but this may lead to image distortion and artifacts, especially in cases of marked brain abnormalities. Person et al [18 ]aimed to assess a block-matching normalization algorithm in which most transformations are not directly computed on the overall brain volume but through small blocks, a principle that is likely to minimize artifacts.…”

Section: Discussionmentioning

confidence: 99%

Glucose Metabolism in the Primary Auditory Cortex of Postlingually Deaf Patients: An FDG-PET Study

Okuda

Nagamachi²,

Ushisako³

et al. 2013

ORL

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Background/Purpose: Previous FDG-PET studies have indicated neuroplasticity in the adult auditory cortex in cases of postlingual deafness. In the mature brain, auditory deprivation decreased neuronal activity in primary auditory and auditory-related cortices. In order to reevaluate these issues, we used statistical analytic software, namely a three-dimensional stereotaxic region of interest template (3DSRT), in addition to statistical parametric mapping (SPM; Institute of Neurology, University College of London, UK). MaterialsandMethods:¹⁸F-FDG brain PET scans were performed on 7 postlingually deaf patients and 10 healthy volunteers. Significant increases and decreases of regional cerebral glucose metabolism in the patient group were estimated by comparing their PET images with those of healthy volunteers using SPM analysis and 3DSRT. Results: SPM revealed that the glucose metabolism of the deaf patients was lower in the right superior temporal gyrus, both middle temporal gyri, left inferior temporal gyrus, right inferior lobulus parietalis, right posterior cingulate gyrus, and left insular cortex than that of the control subjects. 3DSRT data also revealed significantly decreased glucose metabolism in both primary auditory cortices of the postlingually deaf patients. Conclusion: SPM and 3DSRT analyses indicated that glucose metabolism decreased in the primary auditory cortex of the postlingually deaf patients. The previous results of PET studies were confirmed, and our method involving 3DSRT has proved to be useful.

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Section: Discussionmentioning

confidence: 99%