Voxel-based reproducibility of T2 relaxation time in patellar cartilage at 1.5 T with a new validated 3D rigid registration algorithm

Raya, José G.; Horng, Annie; Dietrich, Olaf; Weber, Johannes Heinrich; Dinges, Julia; Mützel, Elisabeth; Reiser, Maximilian; Gläser, Christian

doi:10.1007/s10334-009-0168-0

Cited by 15 publications

(10 citation statements)

References 39 publications

(65 reference statements)

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“…Test-retest reproducibility for both global and regional ADC and FA was in the range of previously reported in vivo data (1.5 T and 3.0 T) for T2 (35)(36)(37)(38) …”

Section: Discussionmentioning

confidence: 99%

Articular Cartilage: In Vivo Diffusion-Tensor Imaging

et al. 2012

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“…Test-retest reproducibility for both global and regional ADC and FA was in the range of previously reported in vivo data (1.5 T and 3.0 T) for T2 (35)(36)(37)(38) …”

Section: Discussionmentioning

confidence: 99%

Articular Cartilage: In Vivo Diffusion-Tensor Imaging

et al. 2012

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“…Previous evaluations of cartilage T2 reproducibility have been limited to single-site single-vendor studies of the patella (16,36,37). In our study, cartilage T2 measurements generally had good to high reproducibility.…”

Section: Discussionmentioning

confidence: 99%

Knee Articular Cartilage Damage in Osteoarthritis: Analysis of MR Image Biomarker Reproducibility in ACRIN-PA 4001 Multicenter Trial

et al. 2011

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Purpose To prospectively determine the reproducibility of quantitative magnetic resonance (MR) imaging biomarkers of the morphology and composition (spin lattice relaxation time in rotating frame [T1-ρ], T2) of knee cartilage in a multicenter multivendor trial involving patients with osteoarthritis (OA) and asymptomatic control subjects. Materials and Methods This study was HIPAA compliant and approved by the institutional review committees of the participating sites, with written informed consent obtained from all participants. Fifty subjects from five sites who were deemed to have normal knee joints (n = 18), mild OA (n = 16), or moderate OA (n = 16) on the basis of Kellgren-Lawrence scores were enrolled. Each participant underwent four sequential 3-T knee MR imaging examinations with use of the same imager and with 2–63 days (median, 18 days) separating the first and last examinations. Water-excited three-dimensional T1-weighted gradient-echo imaging, T1-ρ imaging, and T2 mapping of cartilage in the axial and coronal planes were performed. Biomarker reproducibility was determined by using intraclass correlation coefficients (ICCs) and root-mean-square coefficients of variation (RMS CVs, expressed as percentages). Results Morphometric biomarkers had high reproducibility, with ICCs of 0.989 or greater and RMS CVs lower than 4%. The largest differences between the healthy subjects and the patients with radiographically detected knee OA were those in T1-ρ values, but precision errors were relatively large. Reproducibility of T1-ρ values was higher in the thicker patellar cartilage (ICC range, 0.86–0.93; RMS CV range, 14%–18%) than in the femorotibial joints (ICC range, 0.20–0.84; RMS CV range, 7%–19%). Good to high reproducibility of T2 was observed, with ICCs ranging from 0.61 to 0.98 and RMS CVs ranging from 4% to 14%. Conclusion MR imaging measurements of cartilage morphology, T2, and patellar T1-ρ demonstrated moderate to excellent reproducibility in a clinical trial network.

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“…For comparison, the ranges of CV for different proton‐based MRI techniques for assessing OA in cartilage are cartilage thickness: 2.1–8.3% (28, 29); cartilage volume: 1–7.5% (28, 29); dGEMRIC: 4.7–12.9% (30); T2 mapping: 3–7% for global measurements, 6–29% for regional measurements (31–33); T1ρ mapping: 7–19% (33); diffusion tensor imaging: apparent diffusion coefficient 8.1%, fractional anisotropy 9.7% (34).…”

Section: Discussionmentioning

confidence: 99%

Reproducibility and repeatability of quantitative sodium magnetic resonance imaging in vivo in articular cartilage at 3 T and 7 T

Madelin

Babb

Xia

et al. 2011

Magnetic Resonance in Med

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Osteoarthritis (OA) is a degenerative disease of articular cartilage that may be associated with a loss of glycosaminoglycans (GAG). Quantitative sodium MRI is highly specific to GAG content and could be used to assess the biochemical degradation of cartilage in early OA. However, the reproducibility and repeatability of this technique are not well documented. The aim of this study is to test the repeatability and reproducibility of sodium quantification in cartilage in vivo using intra- and inter-day acquisitions at 3T and 7T, with a 3D radial sequence, with and without fluid suppression. Fluid suppression was obtained by adiabatic inversion recovery (IR WURST), and is expected to improve the sensitivity of the method to GAG content. The root mean square of coefficients of variation (CV) are all in the range of 7.5-13.6%. No significant inter-magnet, inter-sequence, intra-day and inter-day differences in the CV were observed. Sodium quantification using IR WURST gave values closer to those reported in the literature for healthy cartilage (220-310 mM) than 3D radial. In conclusion, IR WURST was more accurate in context of sodium measurement, with a reproducibility and repeatability comparable to other compositional MRI techniques of cartilage.

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Voxel-based reproducibility of T2 relaxation time in patellar cartilage at 1.5 T with a new validated 3D rigid registration algorithm

Abstract: Using a rigid 3D-registration algorithm provides voxel-based T2 reproducibility errors comparable to former, 2D region-based approaches, thus opening the possibility of voxel-based monitoring of cartilage degradation in osteoarthritis.

Cited by 15 publications

References 39 publications

Articular Cartilage: In Vivo Diffusion-Tensor Imaging

Articular Cartilage: In Vivo Diffusion-Tensor Imaging

Knee Articular Cartilage Damage in Osteoarthritis: Analysis of MR Image Biomarker Reproducibility in ACRIN-PA 4001 Multicenter Trial

Reproducibility and repeatability of quantitative sodium magnetic resonance imaging in vivo in articular cartilage at 3 T and 7 T

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