Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis

Resting-state networks in adolescents with 22q11.2 deletion syndrome: Associations with prodromal symptoms and executive functions

“…In the 22q11DS group, increased activation of the posterior medial lSFG was negatively associated to prodromal expression of emotion, suspicious/persecutory ideas and disorganized communication, and positively associated to impulse control and attention. These results are consistent with a meta-analysis covering fMRI studies using emotion processing and executive function paradigms in high-risk for psychosis samples (Fusar-Poli, 2012). Compared to controls in such tasks, this meta-analysis found hypo-activation in SFG, as in other prefrontal areas, to be characteristic of high-risk for psychosis during adolescence.…”

Brain correlates of verbal fluency in subthreshold psychosis assessed by functional near-infrared spectroscopy

“…Particularly, the functionality of prefrontal and temporal cortices, contributing to executive and working memory functions, may provide neurobiological markers of illness onset in psychosis and schizophrenia (Pantelis et al, 2009). In persons with subthreshold psychotic symptoms and subsequent conversion to schizophrenia, reduced activation in prefrontal brain regions and reduced prefrontal-temporal functional connectivity have been reported during verbal fluency performance (Allen et al, 2012;Fusar-Poli et al, 2011;Jung et al, 2012;Sabb et al, 2010), with a gradual decline in prefrontal activation from the subthreshold state to chronic psychosis (Fusar-Poli, 2012;Pantelis et al, 2009).…”

Brain structure in people at ultra-high risk of psychosis, patients with first-episode schizophrenia, and healthy controls: a VBM study

“…Along with the established and validated research criteria for highrisk states for psychosis, there have been several studies investigating neurobiological changes in high-risk populations, including volumetric and voxel-based morphometry (VBM) approaches (for review, see (Jung et al, 2010;Lawrie et al, 2008;Wood et al, 2013)) as well as functional MRI (Fusar-Poli, 2012). Reviews and meta-analyses in this area, however, differ, with regards to the definition and inclusion of high-risk subjects: while some have provided overviews on studies in genetic high-risk relatives (Palaniyappan et al, 2012), others have included studies with a broader spectrum of the high-risk paradigm, including individuals at risk for psychosis not only through affected relatives, but also through either psychometric or subclinical symptom profiles (Chan et al, 2011;Wood et al, 2013).…”