Voxel‐wise meta‐analysis of gray matter abnormalities in idiopathic Parkinson’s disease

Pan, PingLei; Song, Wei; Shang, Huifang

doi:10.1111/j.1468-1331.2011.03474.x

Cited by 104 publications

(85 citation statements)

References 66 publications

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“…The neural substrate of motor and cognitive symptoms has been investigated using non-invasive brain imaging such as structural MRI, which can offer the opportunity of identifying early biomarkers. In fact, different MRI techniques are providing mounting evidence of both gray and white matter changes in PD (Cochrane and Ebmeier 2013;Pan et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

et al. 2014

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The current study investigates both gray and white matter changes in non-demented Parkinson's disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre-and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.

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Section: Introductionmentioning

confidence: 99%

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

et al. 2014

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“…11 GM atrophy was increased in one study of patients with PD. 12 Visual assessment of GM changes did not detect differences between the PD subtypes 13 ; however, this methodologic approach may not have been sufficiently sensitive to detect subtle GM changes.…”

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confidence: 99%

“…Second, the relationship between GM atrophy and clinical symptoms was evaluated in specific regions of interest (ROIs) that were found to be related to PD. 12,[14][15][16] Finally, in regions that showed such a relationship, the association between GM atrophy and functional connectivity within the motor network was examined.…”

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confidence: 99%

“…To define the left inferior frontal gyrus (IFG), which was shown to have robust GM atrophy in patients with PD compared with healthy controls, we selected a sphere of 8 mm around the following Montreal Neurological Institute coordinates: [242, 20,212], as published in a recent meta-analysis study. 12 Resting-state functional connectivity analysis. Functional connectivity detects very low frequency (,0.08 Hz) fluctuations in magnetic resonance signals.…”

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confidence: 99%

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Gray matter atrophy distinguishes between Parkinson disease motor subtypes

Rosenberg‐Katz

Herman²,

Jacob³

et al. 2013

Neurology

150

110

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Objective: To assess differences in gray matter (GM) atrophy between 2 Parkinson disease (PD) subtypes: the tremor dominant (TD) subtype and the postural instability gait difficulty (PIGD) subtype.Methods: Patients were classified as belonging to the predominately PIGD (n 5 30) or predominately TD (n 5 29) subtype. Voxel-based morphometry was used to compare GM in these 2 subtypes and to evaluate correlations between predefined regions of interest and the degree of symptoms. In the regions where GM atrophy was associated with symptoms, the relationship between GM volumes and functional connectivity was examined.Results: GM was reduced in the predominately PIGD group, compared with the predominately TD group, in areas that involve motor, cognitive, limbic, and associative functions (p , 0.05, false discovery rate corrected). Lower GM volumes in the pre-supplementary motor area (SMA) and in the primary motor area were associated with increased severity of PIGD symptoms (r 5 20.42, p , 0.001; r 5 20.38, p , 0.003, respectively). Higher GM volumes within the pre-SMA were associated with stronger functional connectivity between the pre-SMA and the putamen (r 5 0.415, p , 0.025) in the patients with predominately PIGD. Conclusions:In patients with PD, PIGD symptoms are apparently associated with GM atrophy in motor-related regions and decreased functional connectivity. GM degeneration and a related decrease in spontaneous coactivation between cortical and subcortical motor-planning areas may partially account for the unique clinical characteristics of a subset of patients with PD.

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“…In this study, we found that the motor function-related brain areas appear gray matter volume reduction, and PD dyskinesia severity was negatively correlated with its decrease. Pan et al [12] use the meta-analysis study in 17 VBM studies of Parkinson's disease brain cortical atrophy, and a comprehensive analysis found that significant regional gray matter volume reduction is mainly located on the left inferior frontal gyrus (BA47) extended to the left temporal (BA38) and left insula (BA13) in PD patients. Fig.…”

Section: Discussionmentioning

confidence: 99%

Brain gray matter volume changes associated with motor symptoms in patients with Parkinson’s disease

et al. 2015

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Background: Parkinson's disease (PD) is a common neurodegenerative disease. Most studies have found that the histopathological lesion is not only localized at the extrapyramidal area (basal ganglia) but also at the cortex in PD patients. Voxel-based morphometry (VBM) based on the voxel as a unit is described for quantitative detection of density and volume of brain tissue. In this study, VBM was used to investigate the brain gray matter changes associated with motor symptoms in PD patients. Methods: Twelve outpatients with PD and 12 healthy controls were recruited in our hospital from September 2013 to March 2014. VBM was performed on the whole brain of all subjects. Image processing and statistical analysis were performed using SPM8. A two-sample t test and multiple regression analysis were performed. Results were displayed with a threshold of P < 0.01, corrected by false discovery rate (FDR) correction and cluster size >30 voxels.Results: Comparing control healthy subjects with the patients, the data showed that PD patients had reduced gray matter volume in the postcentral gyrus, the right supramarginal center, superior temporal gyrus, precentral gyrus, Brodmann area 41, transverse temporal gyrus, Brodmann area 3, and inferior parietal lobule. The data also found that between gray matter volume and UPDRSIII in PD patients, there were negative correlations in the right middle frontal gyrus, BA06, right precentral gyrus, right superior frontal gyrus, and medial frontal gyrus, and between gray matter volume and Hoehn-Yahr (HY) in PD patients, there were negative correlations in the right middle frontal gyrus, right superior frontal gyrus, BA6, and right precentral gyrus.Conclusions: These data supported that extensive changes associated with motor symptoms in the gray matter volume was mainly located in the related area of movement, which had obvious relevance with the progression of PD.

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Voxel‐wise meta‐analysis of gray matter abnormalities in idiopathic Parkinson’s disease

Cited by 104 publications

References 66 publications

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Gray matter atrophy distinguishes between Parkinson disease motor subtypes

Brain gray matter volume changes associated with motor symptoms in patients with Parkinson’s disease

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