VP06.09: Procedure‐related risk of premature delivery and fetal growth reduction following amniocentesis, transcervical and transabdominal chorionic villus sampling: a retrospective study

Abstract

age (6.5%). In the recent eight years, 46 cases were reported in 12 articles, and 78.3% of these cases were diagnosed by chromosomal microarray (CMA) with or without karyotyping. The reported size of 5p deletion ranged from 0.7 to 39.0 Mb. The proportion of deletion <5, 5-10 and >10Mb was 15%, 15%, and 70%, respectively. The main indications for IPD were ultrasound abnormality (60.9%), an abnormal result on non-invasive prenatal testing (NIPT) (21.7%), and parental translocation carrier (8.7%). Of all 77 cases, 51.9% had ultrasound abnormality, 39.0% had ultrasound brain abnormalities, and 19.5% had abnormal cerebellum. In recent years, first trimester ultrasound abnormalities were reported in 5 cases (10.9%). Conclusions: In recent years, most of the reported cases of 5psyndrome were diagnosed by CMA. The most commonest indication for IPD was ultrasound abnormality, followed by an abnormal result on NIPT and parental translocation carrier. VP06.07 Prenatal ultrasonography of 5p deletion syndrome: literature review