VP45.29: Effectiveness of low‐dose hydroxychloroquine versus placebo for the prevention of severe pneumonia in pregnant women with SARS‐CoV2 infection: PROTOCOL for a randomised controlled trial (HYPREG trial)

Abstract

S Suspicious (all patients were considered suspicious) A Avoid (avoid contact with surgical mask and face shield in all patients and health personnel) R Respiratory (respiratory triage) S Saturation (oxygen saturation) C Critical patient (clinical, biochemical and imaging criteria) O Obstetric (obstetric condition) V Viability (fetal viability) Results: In the General Hospital of Mexico during April-May 2020, 161 patients were hospitalised, 149 as SARS-CoV2 suspects and 12 patients confirmed by rt-PCR, maternal age 27 +-7.5 years, gestational age 39.2 +-2.2 weeks. 83/149 (55.7%) Caesarean section, 66/149 (44.3%) vaginal delivery, so far without maternal or neonatal mortality. With the implementation of the protocol, there is no SARS-CoV2 infection in health personnel. Conclusions: There are limited data on the impact of the current outbreak of COVID-19 in pregnant women, the important thing is to establish management guidelines according to the tools that each care centre has to reduce maternal-fetal morbidity and mortality as well as protect staff from health to work in it. We intend this protocol to be a useful tool for other obstetric care hospitals, we recommend that delivery care be by obstetric indication and not by the positive SARS-CoV2 test. VP45.27 Lung ultrasound in pregnant women with COVID-19 as the unique lung imaging modality