2012
DOI: 10.1523/jneurosci.3359-12.2012
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Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes

Abstract: Members of the vacuolar protein sorting 10 (Vps10) family of receptors (including sortilin, SorL1, SorCS1, SorCS2, and SorCS3) play pleiotropic functions in protein trafficking and intracellular and intercellular signaling in neuronal and non-neuronal cells. Interactions have been documented between Vps10 family members and the retromer coat complex, a key component of the intracellular trafficking apparatus that sorts cargo from the early endosome to the trans-Golgi network. In recent years, genes encoding se… Show more

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Cited by 71 publications
(52 citation statements)
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“…These results strongly suggest that Vps10/sortilin acts downstream or in parallel to Vps35 to mediate protection against TIF4631 . Emerging roles for sortilin proteins in other neurodegenerative diseases, such as FTLD and Alzheimer’s disease (Lane et al, 2012; Reitz et al, 2013) and our results linking sortilin to Vps35 and PD now warrant further examination of a role for sortilin proteins in PD. Our data are consistent with the hypothesis that Tif4631 upregulation causes alterations in translation in the absence of Vps35, which could lead to protein misfolding and impairments in sortilin to cope with these misfolded proteins.…”
Section: Resultsmentioning
confidence: 70%
“…These results strongly suggest that Vps10/sortilin acts downstream or in parallel to Vps35 to mediate protection against TIF4631 . Emerging roles for sortilin proteins in other neurodegenerative diseases, such as FTLD and Alzheimer’s disease (Lane et al, 2012; Reitz et al, 2013) and our results linking sortilin to Vps35 and PD now warrant further examination of a role for sortilin proteins in PD. Our data are consistent with the hypothesis that Tif4631 upregulation causes alterations in translation in the absence of Vps35, which could lead to protein misfolding and impairments in sortilin to cope with these misfolded proteins.…”
Section: Resultsmentioning
confidence: 70%
“…Via the retromer complex and its receptors, the Vps10 family members, APP is recycled from the early endosomal compartments to the TGN . Figure adapted from Lane et al (Lane et al 2012)with permission from Society for Neuroscience.…”
Section: Figurementioning
confidence: 99%
“…In yeast and mammalian cells, retromer binds specific peptide motifs in vacuolar and lysosomal acid hydrolase receptors, respectively, and mediates their recycling from endosomes back to the TGN (Nothwehr et al, 2000;Seaman, 2007;Bonifacino and Hurley, 2008). In addition, retromer-mediated protein sorting has been shown for a range of other transmembrane receptors and revealed retromer functions in processes such as Wntdependent signaling, apoptotic cell clearance, and the prevention of neurodegenerative diseases (Port et al, 2008;Chen et al, 2010;Lane et al, 2012). In plants, retromer components have been implicated in recycling vacuolar sorting receptors (Oliviusson et al, 2006;Kang et al, 2012) and in the vacuolar trafficking of plasma membrane proteins such as PIN-FORMED auxin efflux carriers (Kleine-Vehn et al, 2008;Nodzynski et al, 2013).…”
Section: A Novel Role For Retromer In Immune Receptor-mediated Hrmentioning
confidence: 99%