“…In yeast and mammalian cells, retromer binds specific peptide motifs in vacuolar and lysosomal acid hydrolase receptors, respectively, and mediates their recycling from endosomes back to the TGN (Nothwehr et al, 2000;Seaman, 2007;Bonifacino and Hurley, 2008). In addition, retromer-mediated protein sorting has been shown for a range of other transmembrane receptors and revealed retromer functions in processes such as Wntdependent signaling, apoptotic cell clearance, and the prevention of neurodegenerative diseases (Port et al, 2008;Chen et al, 2010;Lane et al, 2012). In plants, retromer components have been implicated in recycling vacuolar sorting receptors (Oliviusson et al, 2006;Kang et al, 2012) and in the vacuolar trafficking of plasma membrane proteins such as PIN-FORMED auxin efflux carriers (Kleine-Vehn et al, 2008;Nodzynski et al, 2013).…”