VrPET/CT: Development of a rotating multimodality scanner for small-animal imaging

Lage, Eduardo; Vaquero, J.J.; Sisniega, Alejandro; España, Samuel; Tapias, G.; Údias, Ángel; García, V. Munuera; Rodriguez-Ruano, Alexia; Desco, Manuel

doi:10.1109/nssmic.2008.4774465

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…6,21 A two-fold improvement in the number of detection modules in the VrPET scanner compared to rPET-1 version approximately doubles the NECR values. 28 Approximately similar improvements have been achieved for PETbox prototypes when shifting from dual-head model to 4-head box geometry. 41,42 In addition, lower NECR values were reported for PET/MR imaging inserts with small AFOV, such as MRS-PET (61.9 kcps), 74 SimPET-S (42.4 kcps), 101 MADPET4 (29.0 kcps), 71 and the scanner reported by Stortz and colleagues 102 (20.8 kcps).…”

Section: Count-rate Performancementioning

confidence: 71%

“…One of them incorporated LYSO/GSO crystals backed by PSPMTs known as Argus (eXplore Vista), whereas the second one (VrPET/ CT) is a coplanar PET/CT scanner based on V-shaped LYSO detector blocks arranged in a partial ring geometry with a rotating gantry. 27,28 The other coplanar design manufactured by the same company is the rPET-1 composed of 2 rotating planar heads with 45 mm AFOV and TFOV. In comparison to other versions of the rPET scanners with two double-block heads, the rPET-1 suffers from 2-fold lower sensitivity.…”

Section: Brief History Of Preclinical Pet Scannersmentioning

confidence: 99%

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Advances in Preclinical PET Instrumentation

Amirrashedi

Zaidi

2020

PET Clinics

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Section: Count-rate Performancementioning

confidence: 71%

Section: Brief History Of Preclinical Pet Scannersmentioning

confidence: 99%

Advances in Preclinical PET Instrumentation

Amirrashedi

Zaidi

2020

PET Clinics

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“…The PET detector modules were shielded with 150 μm lead to decrease the effect of low-energy X-ray photons while preserving enough detection capability to detect 511 keV photons [20]. Other coplanar designs like VrPET/ CT [21] and rPET-1 [22] were also commercialized. Besides seamless co-registration, fast workflow, and high throughput, simultaneous multimodality imaging permits the screening of abrupt alterations in the biological status of the body just with a single dose of anesthetic agents.…”

Section: Multimodality Imaging: Challenges Benefits and Pitfallsmentioning

confidence: 99%

Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems

Amirrashedi

Zaidi

2020

Clin Transl Imaging

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Aim Over the past two decades, innovations in small-animal positron emission tomography (PET) have reached an impressive level, which has brought countless opportunities to explore the major puzzles in biomedical research. It is a given that pairing information coming from different imaging modalities renders unprecedented knowledge and provides a great insight into various facets of biological systems, such as anatomy, function, physiology, and metabolism in animal models of human diseases, which are difficult to be beaten by standalone PET scanners. The development of bimodal and tri-modal imaging platforms with advanced software solutions dedicated for quantitative studies in small-animals has spurred academic and industrial interest. However, it is undisputed that the potential success of these scanners in filling the translational gap between human and animal findings, hinges to a great extent upon optimization and standardization of relevant parameters and acquisition protocols, which is often overlooked. Methods This article reviews the trends till 2020 in the field of preclinical PET imaging with emphasize on image reconstruction and quantitative corrections implemented on state-of-the-heart hybrid systems. First, the challenges, limitations, and benefits offered by multi-modality imaging systems are described and then, the most commonly used strategies, as well as novel techniques for image reconstruction and image corrections (attenuation, scattering, normalization, motion, and partial volume effect) are presented. The advantages and disadvantages of different methods are also discussed. We also briefly touch upon the factors that should be considered for reliable kinetic modeling and absolute quantitation in preclinical small animal research. Conclusions Multi-modality imaging has attracted a lot of research, particularly in the preclinical portfolio. Nevertheless, more research is still needed to optimize the conceptual design, reach the limits of quantitative imaging and implement standardized protocols for small-animal studies. Without any doubt, exploring the potential advantages of combined imaging units providing optimal image quality and reliable tools for quantification of biological parameters through standardized imaging protocols is one of the goals of translational research.

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“…Rotary positron emission tomography (PET)/CT scanners have been successfully used for whole body scans on human cancer patients (Beyer et al 2000, Shekhar et al 2005) and a Co-registration of nuclear scintigraphic and magnetic resonance data of the equine foot: A multi-modality imaging 'proof of principle' study Pferdeheilkunde 29 586 scanner has been developed for in-vivo imaging of small laboratory animals (Lage et al 2008). In human patients using a combined scanner decreased the scan time by 40% and increased the accuracy of the co-registered images however further work is required to optimise this diagnostic tool for imaging small animals.…”

Section: Figmentioning

confidence: 99%

Co-registration of nuclear scintigraphic and magnetic resonance data of the equine foot: A multi-modality imaging ‘proof of principle’ study

Tranquille¹,

Breingan²,

Collins³

et al. 2013

PHK

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SummaryThree-dimensional (3D) multi-modality imaging (MMI) is frequently used in human medicine but its use in equine diagnostic imaging has yet to be validated. In a proof of principle manner, this study aimed to evaluate 3D MMI co-registration of magnetic resonance (MR) and scintigraphic data for the assessment of equine foot injury. A multi-compartment equine foot phantom was designed and constructed using the Stereolithography Additive Manufacturing process. Images were obtained by MR imaging and by scintigraphy using different copper sulphate concentrations (CuSO 4 ) (for MR imaging) or radiopharmaceutical concentrations (for scintigraphy) respectively, which were introduced into the compartments of the foot phantom to mimic the normal limb appearance for each image modality. Lesions at specific locations were simulated by introducing increased concentrations of CuSO 4 or radiopharmaceutical into the appropriate compartments. 3D scintigraphic data was obtained by rotating the phantom through 360° with dynamic acquisitions performed every 3°. The MR and scintigraphy data were co-registered using proprietary software. MR image assessment showed the individual compartments of the phantom, and the location of a simulated lesion. The presence of increased radiopharmaceutical concentration was clear on scintigraphic images, but anatomical resolution was less clear than MR images. Accurate detection and localisation of simulated lesions were best with 3D coregisteration of the MR and scintigraphic images. In the future, 3D co-registration of scintigraphic and MR images may prove clinically useful to localise and differentiate between active and inactive injury. Issues relating to the practical implementation of 3D MMI in the standing sedated horse are discussed.Keywords: horse / multi-modality imaging / scintigraphy / magnetic resonance imaging / diagnostic imaging Bildregistrierung von Daten aus der nuklearen Szintigraphie und Magnetresonanztomographie des Perdefußes: Eine multimodale bildgebende 'proof of principle' Studie Die drei-dimensionale (3D) multi-modale Bildgebung wird in der Humanmedizin häufig angewandt, ihre Bedeutung in der equinen Bildgebung muss jedoch erst evaluiert werden. Ziel der Studie ist die Untersuchung der 3D multimodalen diagnostischen Bildregistrierung von Daten aus Szintigraphie und Magnetresonanztomographie (MRT) für die Beurteilung von Verletzungen der Pferdezehe. Mit Hilfe des stereolithographischen Manufakturprozesses wurde ein Multikompartment-Modell der Pferdezehe entworfen und hergestellt. Bildgebende Untersuchungen wurde mittels MRT und Szintigraphie durchgeführt. Um ein physiologisches Erscheinungsbild der Zehe für die jeweilige bildgebende Methode zu gewinnen wurden verschiedene Kupfersulfat-(CuSO 4 ) (für MRT) und radiopharmazeutische Konzentrationen (für Szintigraphie) in das Modell injiziert. Läsionen an spezifischen Lokalisationen wurden durch Injektion größerer Konzentrationen von CuSO 4 oder Radiopharmazeutika in den verschiedenen Departments simuliert. Die 3D-Szintigra...

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VrPET/CT: Development of a rotating multimodality scanner for small-animal imaging

Cited by 6 publications

References 8 publications

Advances in Preclinical PET Instrumentation

Advances in Preclinical PET Instrumentation

Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems

Co-registration of nuclear scintigraphic and magnetic resonance data of the equine foot: A multi-modality imaging ‘proof of principle’ study

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