PurposeThe emergence of blockchain technology has the potential to bring about transformative changes in various industries, with supply chain management being a prominent domain of application. This study investigates the strategic performance benefits of using blockchain-enabled traceability systems for improving supply chain quality management.Design/methodology/approachThe present study employed structural equation modelling to analyse data obtained from 200 practitioners working in Indian pharmaceutical companies.FindingsThe results reflect that blockchain-enabled traceability systems have a positive impact on multi-tier quality governance (MQG); supply chain process alignment and coordination (SPAC) and quality centric collaboration (QCC); all of which are the facets of supply chain quality management. Furthermore, when examining the impact of blockchain-enabled traceability systems on firm quality performance and economic performance, the mediation role of SPAC and QCC was confirmed, whereas the mediation role of MQG could not be established.Practical implicationsThe study’s empirical insights offer practical guidance for pharmaceutical manufacturers, regulators and other industry participants seeking to harness the potential of blockchain technology for creating resilient and transparent supply chains that uphold product quality and safety standards.Originality/valueThese findings underscore the significance of blockchain-enabled traceability systems in revolutionizing supply chain quality management practices to achieve superior strategic performance in the pharmaceutical sector.