Vulnerability to Psychopathology and Dimensions of Personality in Patients With Fibromyalgia

Garcia-Fontanals, Alba; Portell, Mariona; García-Blanco, Susanna; Poca-Dias, Violant; Garcia-Fructuoso, Ferran J; López-Ruiz, Marina; Rosado, Teresa Gutiérrez; Gomà‐i‐Freixanet, Montserrat; Deus, Joan

doi:10.1097/ajp.0000000000000506

Cited by 13 publications

(14 citation statements)

References 29 publications

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“…Going a little further, we think that it is even more relevant in FM patients, if we focus in the large differences showed in MCMI-III inventory. In fact, Garcia-Fontanals et al [41] found that 50% of patients with FM showed Dysthymia.…”

Section: Discussionmentioning

confidence: 99%

Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety

López-Ruiz¹,

Losilla

Monfort

et al. 2019

PLoS ONE

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ObjectivesTo determine the psychopathological profile of patients with central sensitization (CS) in a sample of knee osteoarthritis, with and without CS, and fibromyalgia, and to compare their psychopathological profiles.MethodsThe final sample consists of 19 patients with osteoarthritis and CS (mean 66.37 years ± 8.77), 41 osteoarthritis patients without CS (mean 66.8 ± 7.39 years), 47 fibromyalgia patients (mean 46.47 years ± 7.92) and 26 control subjects (mean 51.56 years ± 11.41). The psychopathological profile was evaluated with the Millon Multiaxial Clinical Inventory.ResultsThe average score of MCMI-III reflect higher scores in the fibromyalgia and osteoarthritis-CS groups. Patients with osteoarthritis-CS are more likely to report larger scores in Borderline and Major Depression scales. Fibromyalgia patients are more likely to report more increased scores in Somatoform and Major Depression, versus osteoarthritis-CS group. Fibromyalgia patients versus osteoarthritis without CS are more likely to report higher scores in Schizoid, Depression, Histrionic, Sadistic, Borderline, Somatoform, Posttraumatic Stress Disorder and Major Depression scales.DiscussionPatients with CS have less differences in their psychopathological profiles as well as in both osteoarthritis groups and greatest differences are obtained between the fibromyalgia and osteoarthritis without CS, so perhaps presence of CS is the key to differentiate those groups and not chronic pain. An exhaustive assessment brings more accurate psychopathological profiles, thus better psychological treatment could be applied.

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Section: Discussionmentioning

confidence: 99%

Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety

López-Ruiz¹,

Losilla

Monfort

et al. 2019

PLoS ONE

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“…43 Central pain sensitization is one key domain in FMS. Furthermore, the psychopathological pro le of FMS patients may contribute to the symptoms of FMS 27 . The psychopathological pro le may, on the one hand, contribute to enhanced pain sensation while, on the other hand, chronic pain may give rise to anxiety, depression and stress.…”

Section: Discussionmentioning

confidence: 99%

“…Since self-reported pain pro les do not always match quantitative sensory testing (QST) parameters in FMS patients [24][25][26] the rst major objective of the current study was to investigate whether FMS-related pro les of QST parameters are associated with alterations of the fecal microbiome. Given that FMS is linked with several psychological disturbances 27 , the second major objective was to examine whether FMS-related changes in psychometric scores (depression, anxiety, stress) are coupled to changes in microbial composition. In this way we set out to obtain more speci c information on the relevance of the gut microbiome to the pathophysiology of FMS.…”

Section: Introductionmentioning

confidence: 99%

Fibromyalgia-Associated Hyperalgesia and Psychopathological Alterations are Unrelated to Gut Microbiome Diversity

Weber

Tatzl

Kashofer

et al. 2021

Preprint

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Fibromyalgia-syndrome (FMS) is a complex disease characterized by chronic widespread pain and additional symptoms including depression, cognitive dysfunction (“fibro-fog”) and maldigestion. We examined whether FMS-related pain parameters assessed by quantitative sensory testing (QST) are related to changes of microbial diversity.We recruited 25 patients with FMS and 26 age- and sex-matched healthy controls. Medical background, food habits, psychopathology and quality of life were assessed with questionnaires. Stool samples were analyzed by 16S rRNA gene amplification and sequencing. QST was performed according to the protocol of the German Network for Neuropathic Pain.QST showed that both lemniscal and spinothalamic afferent pathways are altered in FMS patients relative to healthy controls and that peripheral as well as central pain sensitization processes are manifest. Psychometric assessment revealed enhanced scores of depression, anxiety and stress. In contrast, neither the composition nor the alpha- and beta-diversity of the fecal microbiome was changed in FMS patients.FMS patients segregate from healthy controls in various parameters of QST and psychopathology, but not in terms of composition and diversity of the fecal microbiome. Despite consideration of several confounding factors we conclude that the impact of the gut microbiome on the pathophysiology of FMS is limited.

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“…[166][167][168] Harm-avoidance in particular may be relevant given its reported association with deficient pain modulation 169 and with affective symptoms. 170 Perfectionism, type D personality, and alexithymia have also been associated with pain and other bodily symptoms as well as emotional distress and negative cognitive processes. 121,160,[171][172][173] In a study, members of our group have demonstrated that health professionals experienced in managing FM can distinguish patients from controls, as a group, based on single items of a personality profiling tool (NEO-PI-R).…”

Section: C) Temperament and Personalitymentioning

confidence: 99%

An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia – A Call for an Integrative Model

Pinto¹,

Geenen²,

Palavra³

et al. 2020

Preprint

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Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia (FM) has progressed remarkably in recent years. Despite this, currents accounts of FM fail to capture the complex, dynamic and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to synthesise current knowledge on FM, explore and highlight multi-level links and pathways among different systems and build bridges between existing approaches. An extensive panel of international experts in neurophysiology and psychosocial aspects of FM discussed the collected evidence and progressively refined and conceptualized its interpretation. Fibromyalgia is a complex condition resulting from the dynamic interplay between multiple systems and processes. We provided an updated overview of the most relevant observations in FM to date as well as the potential pathways by which they exert they are related and exert their mutual influence, to produce the manifestations commonly associated with FM. This review constituted the first step towards and supported the development of a much needed model capable of integrating the main factors implicated in FM into a single, unified model that may prove valuable in understanding and managing FM.

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Vulnerability to Psychopathology and Dimensions of Personality in Patients With Fibromyalgia

Cited by 13 publications

References 29 publications

Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety

Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety

Fibromyalgia-Associated Hyperalgesia and Psychopathological Alterations are Unrelated to Gut Microbiome Diversity

An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia – A Call for an Integrative Model

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Vulnerability to Psychopathology and Dimensions of Personality in Patients With Fibromyalgia

Cited by 13 publications

References 29 publications

Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety

Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety

Fibromyalgia-Associated Hyperalgesia and Psychopathological Alterations are Unrelated to Gut Microbiome Diversity

An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia &ndash; A Call for an Integrative Model

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An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia – A Call for an Integrative Model