Vulnerability to sodium lactate in panic disorder patients given cognitive-behavioral therapy

Abstract

Six patients with panic disorder who had panicked during sodium lactate infusion were given cognitive-behavioral treatment for 12-24 weeks. After treatment they underwent another lactate infusion, and four patients were rates as having no panic, suggesting that reduced vulnerability to lactate accompanies remission of panic. Controlled trials of cognitive-behavioral therapy and use of lactate infusion as a measure of remission are recommended.

Subclinical Symptoms of Panic Disorder: New Insights into Pathophysiology and Treatment

“…Six patients with panic disorder who had panicked during sodium lactate infusion were given cognitive-behavioral treatment. After treatment they underwent lactate infusion again; 4 of the 6 patients did not panic, suggesting that reduced vulnerability to lactate infusion may be associated with remission of panic [94]. This study highlights the potential importance of biological markers as a measure of remission in panic disorder.…”

“…There is paucity of studies on biological markers of remitted patients with panic disorder [94, 95, 96, 97]. Six patients with panic disorder who had panicked during sodium lactate infusion were given cognitive-behavioral treatment.…”