Vulnerable Plaque Characteristics at Coronary Computed Tomography Angiography

Medaković, Petar; Jukić, Mladen; Biloglav, Zrinka

doi:10.15836/ccar2023.7

Cited by 1 publication

(1 citation statement)

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“…As observed in this study, fibrous cap attenuation was one of the strongest predictors of high-risk plaques. It was found that stable plaques had a fibrous cap thickness of 85 microns, and disrupted and vulnerable plaques had a fibrous cap thickness of 55 microns [ 104 , 105 ]. Two other characteristics distinguished this type of plaque from others: the extent of inflammation within the plaque and the extent of necrosis within the plaque.…”

Section: Pathology Of Coronary Artery Disease and Acute Coronary Eventsmentioning

confidence: 99%

Acute Coronary Syndrome: Disparities of Pathophysiology and Mortality with and without Peripheral Artery Disease

Gherasie

Popescu

Bartos

2023

JPM

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There are a number of devastating complications associated with peripheral artery disease, including limb amputations and acute limb ischemia. Despite the overlap, atherosclerotic diseases have distinct causes that need to be differentiated and managed appropriately. In coronary atherosclerosis, thrombosis is often precipitated by rupture or erosion of fibrous caps around atheromatous plaques, which leads to acute coronary syndrome. Regardless of the extent of atherosclerosis, peripheral artery disease manifests itself as thrombosis. Two-thirds of patients with acute limb ischemia have thrombi associated with insignificant atherosclerosis. A local thrombogenic or remotely embolic basis of critical limb ischemia may be explained by obliterative thrombi in peripheral arteries of patients without coronary artery-like lesions. Studies showed that thrombosis of the above-knee arteries was more commonly due to calcified nodules, which are the least common cause of luminal thrombosis associated with acute coronary events in patients with acute coronary syndrome. Cardiovascular mortality was higher in peripheral artery disease without myocardial infarction/stroke than in myocardial infarction/stroke without peripheral artery disease. The aim of this paper is to gather published data regarding the disparities of acute coronary syndrome with and without peripheral artery disease in terms of pathophysiology and mortality.

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Section: Pathology Of Coronary Artery Disease and Acute Coronary Eventsmentioning

confidence: 99%