Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress–related diseases, such as atherosclerosis

Şahin, Erhan; Psav, Sinem Dabagoglu; Avan, İlker; Candan, Mehmet; Şahıntürk, Varol; Koparal, Ayşe Tansu

doi:10.1177/0960327119833745

Cited by 18 publications

(13 citation statements)

References 38 publications

(36 reference statements)

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“…Table 1 shows secondary metabolites of lichens, their origin, chemical structure and also their beneficial activities including anticancer one. Letharia vulpina methyl (2E)-2-(3-hydroxy-5-oxo-4-phenylfuran-2-ylidene)-2-phenylacetate antiproliferative, antimicrobial, antiangiogenic, [46,47] CAS ID (73622-57-8)…”

Section: Molecular Mechanisms Of Lichen Anticancer Potentialmentioning

confidence: 99%

Anticancer Potential of Lichens’ Secondary Metabolites

et al. 2020

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Lichens produce different classes of phenolic compounds, including anthraquinones, xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed effective biological activities such as antioxidant, antiviral, antibiotics, antifungal, and anticancer. Although no clinical study has been conducted yet, there are number of in vitro and in vivo studies demonstrating anticancer effects of lichen metabolites. The main goal of our work was to review most recent published papers dealing with anticancer activities of secondary metabolites of lichens and point out to their perspective clinical use in cancer management.

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Section: Molecular Mechanisms Of Lichen Anticancer Potentialmentioning

confidence: 99%

Anticancer Potential of Lichens’ Secondary Metabolites

et al. 2020

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“…It has been shown to have many beneficial effects, and its therapeutic value increases day by day. Vulpinic acid, a lichen compound, has been shown to have antiproliferative, antiangiogenic, antimicrobial, and protective effects against ultraviolet rays in cancer cells (Sahin et al, 2019).…”

Section: Vulpinic Acidmentioning

confidence: 99%

Antiangiogenic properties of lichen secondary metabolites

Ulus

2021

Phytotherapy Research

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Lichens are symbiotic organisms which are composed fungi and algae and/or cyanobacteria. They produce a variety of characteristic secondary metabolites. Such substances have various biological properties including antimicrobial, antiviral, and antitumor activities. Angiogenesis, the growth of new vessels from pre-existing vessels, contributes to numerous diseases including cancer, arthritis, atherosclerosis, infectious, and immune disorders. Antiangiogenic therapy is a promising approach for the treatment of such diseases by inhibiting the new vessel formation. Technological advances have led to the development of various antiangiogenic agents and have made possible antiangiogenic therapy in many diseases associated with angiogenesis. Some lichens and their metabolites are used in the drug industry, but many have not yet been tested for their antiangiogenic effects. The cytotoxic and angiogenic capacities of lichen-derived small molecules have been demonstrated in vivo and in vitro experiments. Therefore, some of them may be used as antiangiogenic agents in the future. The secondary compounds of lichen whose antiangiogenic effect has been studied in the literature are usnic acid, barbatolic acid, vulpinic acid, olivetoric acid, emodin, secalonic acid D, and parietin. In this article, we review the antiangiogenic effects and cellular targets of these lichen-derived metabolites.

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“…There is speculation that the pulvinic acid derivatives protect the lichen from some herbivores and have an antibacterial activity against gram-positive bacteria [19]. Vulpinic acid from this lichen has emerged recently as a potential drug candidate in the therapy of atherosclerosis [20]. Lepraria incana (L.) Ach.…”

Section: Introductionmentioning

confidence: 99%

Chrysoviruses Inhabited Symbiotic Fungi of Lichens

Petrzik

Koloniuk

Sehadová

et al. 2019

Viruses

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A lichen body is formed most often from green alga cells trapped in a net of ascomycetous fungi and accompanied by endolichenic or parasitic fungi, other algae, and symbiotic or free-living bacteria. The lichen’s microcosmos is inhabited by mites, insects, and other animals for which the lichen is a source of food or a place to live. Novel, four-segmented dsRNA viruses were detected in saxicolous Chrysothrix chlorina and Lepraria incana lichens. Comparison of encoded genome proteins revealed classification of the viruses to the genus Alphachrysovirus and a relationship to chrysoviruses from filamentous ascomycetous fungi. We propose the names Chrysothrix chrysovirus 1 (CcCV1) and Lepraria chrysovirus 1 (LiCV1) as acronyms for these viruses. Surprisingly, observation of Chrysothrix chlorina hybridization with fluorescent-labelled virus probe by confocal microscope revealed that the CcCV1 virus is not present in the lichen body-forming fungus but in accompanying endolichenic Penicillium citreosulfuratum fungus. These are the first descriptions of mycoviruses from a lichen environment.

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Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress–related diseases, such as atherosclerosis

Cited by 18 publications

References 38 publications

Anticancer Potential of Lichens’ Secondary Metabolites

Anticancer Potential of Lichens’ Secondary Metabolites

Antiangiogenic properties of lichen secondary metabolites

Chrysoviruses Inhabited Symbiotic Fungi of Lichens

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