Vulvar basal cell carcinoma arising in the setting of repeated perilamp exposure

McEnery-Stonelake, Melissa; Clark, Melanie A.; Vidimos, Allison

doi:10.1016/j.jdcr.2019.11.001

Cited by 3 publications

(8 citation statements)

References 9 publications

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“…BCC arising in uncommon locations, such as the oral cavity or the vulva is not associated with UV radiation exposure as a primary risk factor, as these are sun-protected areas. In such rare primary site cases, other risk factors are involved, such as chronic inflammation, immune suppression, Paget's disease of the vulva or lichen sclerosus, addressing the genital location; as regards the oral cavity, risk factors for BCC development remain unknown ( 22-24 ). Although vitiligo may be a predisposing factor for sunburn, and it may potentiate the effects of UV radiation and subsequent consequences, the available data reveal the contrary, a protective effect; the association between vitiligo and BCC is rare, as it is also in the case of melanoma ( 25-28 ).…”

Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

Basal cell carcinoma: Comprehensive clinical and histopathological aspects, novel imaging tools and therapeutic approaches (Review)

et al. 2021

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Basal cell carcinoma (BCC) is one of the most common malignant tumors worldwide, involving the skin. It is also part of keratinocyte carcinomas, alongside its squamous counterpart. It has low mortality and extremely low metastatic rates (although when present, it indicates a poor patient prognosis); it also has a high morbidity rate through local destruction and recurrence, particularly when perineural invasion is observed, clinically or histopathologically. BCC development is the result of environmental and patient factors, with genetics and ultraviolet radiation playing major roles. The clinical and histopathological aspects vary according to tumor subtype, being classified as high-risk tumors (nodular, superficial, pigmented and infundibulocystic BCC with adnexal differentiation) and fibroepithelial subtypes, or as high-risk tumors (micronodular, infiltrating, sclerosing/morphoeic and basosquamous subtype or the type with sarcomatoid differentiation). Dermoscopy is now complimented by novel in vivo diagnostic tools (optical coherence tomography, reflectance confocal microscopy, high-resolution ultrasonography, Raman spectroscopy or terahertz pulse imaging), improving the diagnostic accuracy and providing tumor depth and lateral margins without the use of invasive techniques. Novel treatment approaches for the treatment of BCC have recently been investigated with the use of hedgehog pathway inhibitors, such as Vismodegib. These approaches aim for complete resolution, minimal side-effects, high patient satisfaction with the optimal cosmetic results, particularly in key areas, such as the face. The present review article summarizes and discusses the comprehensive clinical and histopathological aspects of BCC, and presents novel imaging tools and therapeutic approaches that have been identified.

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Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

Basal cell carcinoma: Comprehensive clinical and histopathological aspects, novel imaging tools and therapeutic approaches (Review)

et al. 2021

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“…Heat-induced basal cell carcinomas account for less than one percent of all basal cell carcinomas, and basal cell carcinomas make up 12 percent of tumors that develop on burn scars. Treatment for these malignancies often requires excision of the tumor [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…The morphology of basal cell carcinomas is variable; it ranges from a flesh-colored papule to a pink, raised, shiny plaque [3][4][5]. Pathology shows aggregates of basaloid tumor cells with hyperchromatic and large nuclei, minimal cytoplasm, and peripheral palisading.…”

Section: Discussionmentioning

confidence: 99%

“…Pathology shows aggregates of basaloid tumor cells with hyperchromatic and large nuclei, minimal cytoplasm, and peripheral palisading. Basal cell carcinomas can result from previous burns or the use of rimless glasses or heated lamps [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…She had received twice daily treatment with the lamp after each of her five pregnancies. The repeated infrared radiation exposure was postulated to be the cause of her vulvar basal cell carcinoma [3].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Heater-Associated Erythema Ab Igne: Case Report and Review of Thermal-Related Skin Conditions

Forouzan¹,

Riahi²,

Cohen³

2020

Cureus

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Erythema ab igne is a thermal-associated skin condition that can occur secondary to persistent direct or indirect contact with heat. Historically, erythema ab igne has been linked to fireplace and stove exposures; more recently, it has been associated with heaters, hot water bottles, and laptops. A 48-year-old woman presented for the evaluation of hyperpigmented, reticulated macular lesions on her distal legs. Additional history revealed that she had developed erythema ab igne secondary to the use of a space heater underneath her desk at work. Her skin condition stopped progressing with removal of the causative agent. In addition to erythema ab igne, heatrelated skin conditions include basal cell carcinomas and squamous cell carcinomas, burns, erythromelalgia, subtypes of urticaria, and ultraviolet-associated disorders. Awareness of thermal-associated skin conditions enables the clinician to establish the appropriate diagnosis based on the associated history of the condition, the morphology of the skin lesion, and, if necessary, correlation with the skin biopsy findings of the cutaneous condition.

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Vulvar basal cell carcinoma: A case report and literature review

Aminimoghadam,

Marzban,

Ghaemi

et al. 2023

International Journal of Surgery Case Reports

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Vulvar basal cell carcinoma arising in the setting of repeated perilamp exposure

Cited by 3 publications

References 9 publications

Basal cell carcinoma: Comprehensive clinical and histopathological aspects, novel imaging tools and therapeutic approaches (Review)

Basal cell carcinoma: Comprehensive clinical and histopathological aspects, novel imaging tools and therapeutic approaches (Review)

Heater-Associated Erythema Ab Igne: Case Report and Review of Thermal-Related Skin Conditions

Vulvar basal cell carcinoma: A case report and literature review

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