Vulvar Cancer in Human Immunodeficiency Virus-Seropositive Premenopausal Women: A Case Series and Review of the Literature

Abstract

This review describes three cases of human immunodeficiency virus-infected women who were diagnosed with vulvar cancer before age 40 years. A retrospective chart review was performed for three patients who were younger than 40 years of age and who had histologically confirmed invasive squamous cell carcinoma of the vulva diagnosed between 1999 and 2002. Demographic, clinical, and laboratory data were recorded. Three human immunodeficiency virus-seropositive women were diagnosed with invasive squamous cell carcinoma of the vulva, stages IA, IB1, and III. All cases were characterized by extensive surrounding vulvar, vaginal, and cervical intraepithelial neoplasia. CD4 cell counts were 250, 330, and 900 cells/uL. Two patients experienced previous acquired immune deficiency syndrome-defining illnesses: toxoplasmosis and cervical cancer. Vulvar cancer in young human immunodeficiency virus-seropositive women may be associated with other human papillomavirus-related diseases and immunosuppression, as evidenced by low CD4 counts and the presence of antecedent acquired immune deficiency syndrome-defining illnesses.

Negative p53 expression and negative high risk HPV in a 26-year-old lady with vulvar keratinizing squamous cell carcinoma: report of a case

“…Few other reported cases of vulvar SCC in young patients were found. However, a substantial number of them were reported in association with HIV infection [13][14][15][16][17]. Some reported cases were also strangely diagnosed during pregnancy [18][19][20].…”

Carcinome épidermoïde de la vulve chez une patiente infectée par le VIH-1 en échec de traitement antirétroviral de première ligne

“…Le carcinome épidermoïde de la vulve constitue la variété histologique la plus fréquente [ 4 ]. L´infection à VIH augmente le risque de survenue chez les femmes séropositives de cancers de la vulve [ 5 ] du fait de la forte prévalence de l´infection à HPV chez elles [ 6 ]. Nous rapportons ainsi le cas d´un carcinome épidermoïde de la vulve chez une patiente infectée par le VIH-1 en échec de traitement ARV de première ligne dont l´évolution a été marquée par le décès dans un tableau de choc septique.…”