1996
DOI: 10.1006/gyno.1996.0255
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Vulvar Eccrine Porocarcinoma

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Cited by 22 publications
(24 citation statements)
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“…The routine dissection of regional lymph nodes remains controversial, although lymphadenectomy is indicated for patients with clinically enlarged nodes. Radiation therapy for EPC is ineffective for the control of recurrence or metastatic disease [3, 5]. In addition, metastatic EPC has proven resistant to many cytotoxic agents [13].…”
Section: Discussionmentioning
confidence: 99%
“…The routine dissection of regional lymph nodes remains controversial, although lymphadenectomy is indicated for patients with clinically enlarged nodes. Radiation therapy for EPC is ineffective for the control of recurrence or metastatic disease [3, 5]. In addition, metastatic EPC has proven resistant to many cytotoxic agents [13].…”
Section: Discussionmentioning
confidence: 99%
“…Vulvar porocarcinoma appears to most often affect women in the sixth decade, and, similar to porocarcinomas at other sites, vulvar porocarcinomas are associated with frequent nodal metastases. [83][84][85][86] The main histologic mimic is squamous cell carcinoma, and a panel of cytokeratin 19 and cytokeratin 7 is considered helpful. 87 Regarding molecular studies, TP53 and PIK3CA mutations and EGFR gene polysomy have been documented in rare cases of porocarcinomas.…”
mentioning
confidence: 99%
“…Sex bias has not been clearly demonstrated in this study, with male and female patients equally affected (2,6,7,12,15,(17)(18)(19). There may be distant metastases in 25% of cases to sites such as regional or distant lymph nodes, retroperitoneum, peritoneum, femur, breast, liver, bladder, ovary, adrenal glands, lungs and brain (6,7,12,15,(17)(18)(19)(20)(21)(22).…”
Section: Natural Historymentioning
confidence: 83%