Vulvar Lesions in an 8-Year-Old Girl: Cutaneous Manifestations of Multisystem Langerhans Cell Histiocytosis

Jorgensen, Eugéne C.; Chen, Peter P.; Rutter, Sarah; Cron, Julia

doi:10.1016/j.jpag.2017.09.010

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…RCM allows the noninvasive visualization of microanatomic structures 14 , which can visualize high resolution of atypical Langerhans cells and microscopic structure of epidermis and superficial dermis of LCH lesions 14 . It mainly manifested a significant increase of epidermotrophic Langerhans cells with a mixed inflammatory background, atypical Langerhans cells showed abundant eosinophilic cytoplasm with numerous mitochondria, vacuoles, dense bodies, a well‐developed Golgi apparatus and numerous Langerhans' cell granules 12,17,18 . In our study, although LCH had different clinical manifestations based on anatomical locations, the RCM features of all LCH rash were consistent.…”

Section: Discussionmentioning

confidence: 71%

“…14 It mainly manifested a significant increase of epidermotrophic Langerhans cells with a mixed inflammatory background, atypical Langerhans cells showed abundant eosinophilic cytoplasm with numerous mitochondria, vacuoles, dense bodies, a well-developed Golgi apparatus and numerous Langerhans' cell granules. 12,17,18 to the common pathological features of LCH. Our results were consistent with the previous publishes.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical features of VLCH in children were significantly different from those in adults and other anatomic locations, which might be attributed to friction parts. The previous study demonstrated that VLCH and NLCH might indicate high morbidity of multi‐system involvement and poor prognosis, 12 , 18 which should be highly valued. LCH was definitively diagnosed by histopathology, however, the biopsy is an invasive approach, and guardian tend to hold a high threshold to it.…”

Section: Discussionmentioning

confidence: 99%

“…8 Among all the organs, LCH occurring in vulvar and nail was extremely rare for children, its dermoscopic and RCM features had been less investigated, meanwhile, nail LCH (NLCH) and vulvar LCH (VLCH) indicated the herald symptom of underlying multisystem disease. 11,12 We retrieved the papers in the fields of LCH, dermoscopy, and RCM from the NCBI, Web of Science, and Google of database, the dermatoscopic and RCM features of VLCH have less been investigated. We found that the clinical characteristics of children VLCH and/or N LCH (presented onycholysis and purpuric striae 13 ) were different from those of adults and other anatomic locations and were also prone misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Among all the organs, LCH occurring in vulvar and nail was extremely rare for children, its dermoscopic and RCM features had been less investigated, meanwhile, nail LCH (NLCH) and vulvar LCH (VLCH) indicated the herald symptom of underlying multisystem disease 11,12 . We retrieved the papers in the fields of LCH, dermoscopy, and RCM from the NCBI, Web of Science, and Google of database, the dermatoscopic and RCM features of VLCH have less been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Dermoscopy and reflectance confocal microscopy finding of different anatomic sites of Langerhans cell histiocytosis

Zhang,

Wang,

Wang

et al. 2024

Skin Research and Technology

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BackgroundRecognizing Langerhans cell histiocytosis (LCH) might be a challenge due to its rarity. Reflectance confocal microscopy (RCM) and dermoscopy were emergent promising non‐invasive technique as auxiliary tools in diagnosis of different skin conditions. However, the RCM and dermoscopic features of LCH had been less investigated. To reveal the common RCM and dermoscopic features of LCH.Materials and methodsForty cases of LCH were retrospectively analyzed according to age, locations, clinical, RCM, and dermoscopic features from September 2016 to December 2022. To reveal the differences and common in clinical, RCM, and dermoscopic features that occur in different anatomic location.ResultsIn the study, sites of predilection include the trunk 31/40 (77.5%), extremity 21/40 (52.5%), face 14/40 (35%), scalp 11/40 (27.5%), vulvar 4/40 (10%), and nail 2/40 (5%). All LCHs had the common RCM features. There were significant differences in clinical and dermoscopic features for age and lesion anatomic site. The common dermoscopic features for scalp, face, trunk, and extremity were the erythematous scaly rash, purplish‐red globules or patches, scar‐like streaks with ectatic vessels. While the features for nail LCH were purpuric striae, onycholysis and purulent scaly rash, and the erosive erythematous plaque and purulent scaly rash for vulvar LCH. The common RCM features of all LCH showed a focal highly reflective dense image in the surface keratin layer, epidermis architectural disarray, obscuration of dermo‐epidermal junction, numerous polygonal, large, medium reflective, short dendrites cells in the epidermis, and dermis. All LCH involving the vulvar and nail did not manifest skin lesions.ConclusionRCM and dermoscopy showed promising value for diagnosis and differentiation of LCH.

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Section: Discussionmentioning

confidence: 71%