Vulvar malignant pleomorphic adenoma in a patient with lichen sclerosus

Hieta, Niina; Kurki, Samu; Rintala, Marjut; Hietanen, Sakari; Katri, Orte J.

doi:10.1016/j.jdcr.2019.09.013

Cited by 1 publication

(3 citation statements)

References 12 publications

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“…In MGLSc the published rates vary between 0% and 12.5% (with the lower figures from our group, testifying to early, accurate diagnosis and effective definitive treatment) 19–22 . GLSc has also been reported in association with other neoplasms, including Merkel cell carcinoma, spindle cell carcinoma, vulvar malignant pleomorphic adenoma and basal cell carcinoma, as well as with benign nevi 9,23–26 …”

Section: Discussionmentioning

confidence: 65%

“… 19 , 20 , 21 , 22 GLSc has also been reported in association with other neoplasms, including Merkel cell carcinoma, spindle cell carcinoma, vulvar malignant pleomorphic adenoma and basal cell carcinoma, as well as with benign nevi. 9 , 23 , 24 , 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

“…[19][20][21][22] GLSc has also been reported in association with other neoplasms, including Merkel cell carcinoma, spindle cell carcinoma, vulvar malignant pleomorphic adenoma and basal cell carcinoma, as well as with benign nevi. 9,[23][24][25][26] VuSCC emanating from FGLSc has been postulated to be a consequence of the molecularly altered epithelium created by chronic inflammation and abnormal cytokine and growth-factor production. 11,27 In men, the carcinogenic pathway has not previously generated much comment or research but is an active area of investigation by our group.…”

Section: What Does This Study Add?mentioning

confidence: 99%

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Genital lichen sclerosus and melanoma; a systematic review

Sim

Dear

Mastoraki

et al. 2022

Skin Health and Disease

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Background Lichen sclerosus (LSc) is a chronic, inflammatory, destructive skin disease with a predilection for the genitalia (GLSc). An association with vulval (Vu) and penile (Pe) squamous carcinoma (SCC) is now well established but melanoma (MM) has only rarely been reported complicating GLSc. Methods We have performed a systematic literature review of GLSc in patients with genital melanoma (GMM). Only articles that mentioned both GMM and LSc affecting either the penis or vulva were included. Results Twelve studies with a total of 20 patients were included. Our review shows that an association of GLSc with GMM has been more frequently reported in women and female children than men viz, 17 cases compared with three. It is notable that five of the cases (27.8%) concerned female children aged under twelve. Discussion These data suggest a rare association between GLSc and GMM. If proven, there arise intriguing questions about pathogenesis and consequences for counselling of patients and follow‐up.

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Section: Discussionmentioning

confidence: 65%