Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2

Chokoeva, Anastasiya Atanasova; Tchernev, Georgi; Cardoso, JC; Jw, Patterson; Dechev, I.; Valkanov, St.; Zanardelli, Matteo; Lotti, Torello; Wollina, Uwe

doi:10.1177/0394632015575977

Cited by 19 publications

(11 citation statements)

References 60 publications

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“…VS is a heterogeneous disease with several histological subtypes [3,4]. In our institution, VS accounted for 3.9% of contemporaneous vulvar malignancies.…”

Section: Discussionmentioning

confidence: 74%

“…It is an aggressive malignancy that usually affects women of reproductive age [2]. The histological type of VS is heterogeneous and mainly includes leiomyosarcoma, dermato brosarcoma protuberans, angiosarcoma, rhabdomyosarcoma and epithelioid sarcoma [3,4]. Unlike other vulvar malignancies, VS usually grows with benign appearance and non-speci c manifestation, which increases the di culty of early diagnosis [5].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Features and Treatment Outcomes of Vulvar Sarcoma: A Single-Institution Review of 21 Cases

Gu¹,

Liu²,

Liu³

et al. 2020

Preprint

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BackgroundValvar sarcoma is an extremely rare disease in which the data for treatment and prognosis are scarce. The aim of this study was to analysis the clinical features and treatment outcomes of initial and recurrent valvar sarcoma.MethodThe medical records of patients with initial or recurrent vulvar sarcoma treated at Sun Yat-sen University Cancer Center between January 2005 and April 2019 were retrospectively reviewed.Results A total of 21 patients with vulvar sarcoma were identified. The median age of them was 43 years (range: 16 to 71). The histological subtypes were epithelioid sarcoma, leiomyosarcoma, dermatofibrosarcoma protuberans, rhabdomyosarcoma, and angiosarcoma in 9, 4, 4, 3 and 1 patients, respectively. None of the patients received wide resection when they were initially treated at communities. Thirteen patients were referred immediately after initial managements (Group A), whereas 8 patients were referred with recurrent disease (Group B). Wide resections were performed with pathologically negative margins in 20 patients, of whom 9 also received lymphadenectomy and 3 showed metastases. One patient in Group B only received chemoradiotherapy for unresectable pelvic mass. Adjuvant chemoradiotherapy were performed for 12 patients evaluated to have high risk of recurrence. The median follow-up time was 39 months (range: 11 to 174) for Group A and 107 (range: 2 to 139) for Group B. During the follow-up, relapse occurred in 3 patients in Group A and 5 in Group B. The 3- and 5-year survival rates were 92.3% and 76.9% for Group A, 50.0% and 37.5% for Group B, respectively.ConclusionsVS is usually resected as benign disease at initial management. Immediate extended resection with negative margins provided favorable outcomes for most of the patients. The prognosis for recurrent cases were poor, however there remained survival opportunities if aggressive treatments were carried out.

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“…VS is a heterogeneous disease with several histological subtypes [3,4]. In our institution, VS accounted for 3.9% of contemporaneous vulvar malignancies.…”

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Clinical Features and Treatment Outcomes of Vulvar Sarcoma: A Single-Institution Review of 21 Cases

Gu¹,

Liu²,

Liu³

et al. 2020

Preprint

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“…A recent review shows their importance as markers in cancer (12). Some of these tumors may express oestrogen, progesterone, and androgen receptors (15)(16)(17)(18), the signi cance of which for the development of these tumors is not fully understood (19). Therefore, for our case, we did the smooth muscle cell markers to aid in the differential with malignancy.…”

Section: Discussionmentioning

confidence: 99%

Challenges in Management of Bartholin gland Leiomyoma: A Case Report

Vinturache

Ismail

Damato

et al. 2020

Preprint

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Abstract Background: Leiomyomas are uncommon vulvar neoplasms often misdiagnosed as other Bartholin gland pathology. Due to their rarity and the absence of guidelines, their diagnosis and management remain challenging, largely based on expert opinion and evidence from case reports. Case Presentation: This case report describes a 44-year-old woman presenting with accelerating growth of a vulvar mass. Based on clinical signs and symptoms, the initial diagnosis was Bartholin cyst. Surgical excision was provided for symptom control and aesthetic reasons. The histopathologic diagnosis was vulvar leiomyoma. The postoperative recovery was complicated by secondary haematoma and dehiscence of the surgical site. There was no recurrence at two years follow up. Therefore, we discuss the dilemma posed by physical examination of a vulvar mass, the challenges of the management, and report on secondary morbidity and long-term follow up, aspects of care for patients with vulvar pathology not commonly addressed in the literature. Conclusions: Bartholin gland neoplasms are rare tumors, commonly misdiagnosed as Bartholin’s cysts. Excision is the treatment of choice. Short time follow up allows prompt management of potential postoperative complications. Continuing long term follow up is recommended due to recurrence risk.

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“…The main morphology of ES is usually a lobulated architecture with solid aggregate of cells, forming sometimes rosettes [12]. Histologically, monomorphic population of small round blue cells, not well defined borders, scanty cytoplasm glycogen and high mitotic index are typical features of ES.…”

Section: Discussionmentioning

confidence: 99%

Primary Vulvar Ewing Sarcoma in a 30-Year-Old Woman: A Case Report

Sidibé¹,

Ouahbi²,

Kanab³

et al. 2018

CRCM

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Primary Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are considered as Ewing sarcoma family of tumors (ESFT), characterized by chromosomal translocation t(11; 22) (q24; q12) leading to a chimeric transcript EWS-FLI1 in 85% of cases. It typically involves the soft tissues of the chest wall, pelvis, paravertebral region, abdominal wall, retroperitoneal region and extremities in children, adolescents and young adults. It rarely occurs in the female genital tract. We report an extremely rare case of advanced vulvar Ewing sarcoma/PNET of the vulva confirmed by Fluorescence In Situ Hybridization (FISH) in a 30-year-old woman. The patient was treated by 6 cycles of chemotherapy followed by radiotherapy with favourable outcome. 242Case Reports in Clinical Medicine rarely found in the female genital tract, with occasional reports of tumors arising in the vulva, vagina, cervix, uterine corpus, broad ligament, and ovary [4].Here, we present a case of 30-year-old woman with a confirmed ES arising in the vulva and we report a systematic review of the published literature regarding primary vulvar ES.

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Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2

Cited by 19 publications

References 60 publications

Clinical Features and Treatment Outcomes of Vulvar Sarcoma: A Single-Institution Review of 21 Cases

Clinical Features and Treatment Outcomes of Vulvar Sarcoma: A Single-Institution Review of 21 Cases

Challenges in Management of Bartholin gland Leiomyoma: A Case Report

Primary Vulvar Ewing Sarcoma in a 30-Year-Old Woman: A Case Report

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