Vulvar Squamous Cell Carcinoma in a Patient with AIDS: A Case Study

Abstract

Vulvar cancer comprises 5% of gynecological cancers with squamous cell carcinoma (SCC) being found in 90% of the cases. Vulvar intraepithelial neoplasia is human papilloma virus (HPV)-driven and is the precursor lesion in nearly 40% of all cases of vulvar SCC. Pruritus is reported as the most common initial manifestation of vulvar SCC which may be of a long duration with pain, discharge, and bleeding been less frequently reported which contributes to the delayed initial presentation of the disease. So far, there are no recommended screening strategies for vulvar cancer and HPV vaccination may be the only effective way for prevention. We present a case of advanced vulvar cancer in an immunocompromised host. We will review pertinent topics for the clinicians on HPV infection prevention, clinical course, staging and the need for strong efforts on patient education.

The Use of Native Flora/Herbal Products in Human Papilloma Virus (HPV) Infection: A Global Perspective Study

“…HPV is known to be the most sexually transmitted infection and 40 types of HPV can infect humans. HPV is also implicated in the proliferation of not only CC but other types of cancers [1,16]. Therefore, eradication or ameliorating of HPV infection becomes imperative and necessary.…”

“…HPV is known to be the cause of 70% of cervical cancer and other cancers such as vulva cancer, Papillomas/ Carcinomas, vagina, penis, and oropharynx cancers. Additionally, 630,000 cases of HPV-related cancers are diagnosed each year [1,[16][17][18].…”