Vulvar vestibulitis: Prevalence and historic features in a general gynecologic practice population

Goetsch, Martha F.

doi:10.1016/0002-9378(91)91444-2

Cited by 233 publications

(164 citation statements)

References 4 publications

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“…As previously shown, a high percentage of the women in this study had interrupted act of sexual intercourse due to unbearable pain and unsatisfactory sex and in addition the women expressed fear for the relations existence [27,28].…”

Section: Discussionsupporting

confidence: 49%

Sensory Neuropeptides, Serotonin Innervations and Personality in Women with Vulvodynia

Naessén

Sundström²,

Rahm³

2015

J Clin Exp Dermatol Res

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Objective: The pathophysiology of vulvadynia is still unclear. We evaluated the general innervations of the nerves, the sensory neuropeptides in the vestibular area in eighteen women with vulvadynia, aged 20-38. The same individual acted as her own control and biopsies were taken from affected and none affected areas of posterior wall of the vulval vestibule. Quantitative immunohistochemistry was performed, using antisera to the general neuronal marker protein gene product (PGP) 9.5 and to the sensory neuropeptides substance P and calcitonin gene-related peptide (CGRP). Pain and stress assessments were made. Results:The number of PGP 9.5 immunoreactive in the affected areas showed an increase in number (p=0.06) compared to control sites (p=0.40), but the result did not reached to significance. High scores for pain sensation, signs of burnout, emotional and physical symptoms of stress and anxiety were indicated, regardless of time in all women.Conclusions: An increase in PGP 9.5 immunoreactive nerve fibers may be either secondary to nerve sprouting, or may represent neural hyperplasia, which could be applied as an objective diagnostic finding in vulvadynia. Further studies needed for the neuromediator's roll and inter individual factors for the diagnosis. Vulvodynia seem lead to chronic pain, hence having negative impact on the couple's relationship and the quality of life of women in several ways.

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Section: Discussionsupporting

confidence: 49%

Sensory Neuropeptides, Serotonin Innervations and Personality in Women with Vulvodynia

Naessén

Sundström²,

Rahm³

2015

J Clin Exp Dermatol Res

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“…Sample size was determined by using estimates of a 15-18% prevalence of vulvodynia. 3,5 Participants answered a 30-minute questionnaire that assessed demographics, medical history, and healthcare utilization. Symptomatic women also provided a pain history.…”

Section: Methodsmentioning

confidence: 99%

“…The lifetime prevalence of this condition has been reported as high as 28% in the adult population, although populationbased studies are limited. [2][3][4][5][6] Current literature supports associations between vulvodynia and fibromyalgia, chronic fatigue syndrome, 7 pain with first tampon use, 4 yeast infections, 4,7 recurrent vulvovaginal infections, 4, 7-10 irritable bowel syndrome, 7 interstitial cystitis, 11 and oral contraceptive use. 12 The burden imposed on the healthcare system by vulvodynia has yet to be well characterized.…”

Section: Introductionmentioning

confidence: 99%

Assessment of vulvodynia symptoms in a sample of US women: a prevalence survey with a nested case control study

Arnold¹,

Bachmann²,

Rosen³

et al. 2007

American Journal of Obstetrics and Gynecology

153

118

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Objective-Vulvodynia is a chronic pain syndrome of unknown etiology with scant data on frequency. This study assessed the prevalence of vulvodynia symptoms in a sample of U.S. women and compared health characteristics of symptomatic and asymptomatic women.Study Design-A phone survey contacted 2,127 U.S. households to identify 100 symptomatic women, who were matched on age and time-zone to 325 asymptomatic controls. Odds ratios and logistic regression were used to model associations between pain, medical conditions, and healthcare utilization variables.Results-Current vulvar pain of at least 6 months duration was reported by 3.8% of respondents, with a 9.9% lifetime prevalence. Forty-five percent of women with pain reported an adverse effect on their sexual life and 27% an adverse effect on their life style. Cases more frequently reported repeated urinary tract infections (OR, 6.15; 95% CI,) and yeast infections (OR, 4.24; 95% CI,). Associations existed with chronic fatigue syndrome (OR, 2.78; 95% CI, 1.33-6.19), fibromyalgia (OR, 2.15; 95% CI, 1.06-4.36), depression (OR, 2.99; 95% CI,, and irritable bowel syndrome (OR, 1.86; 95% CI,).Conclusions-Lifetime chronic vulvar pain was less prevalent in this national sample of women than previous data suggest and was correlated with several co-morbid chronic medical conditions and substantial reduction in self-reported quality of life.

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“…Esto permite estimar que al menos 14 millones de mujeres en EEUU, pueden padecer de V (4,13), y sólo dos tercios consultarán un médico por esta razón (14). Un 15% de las mujeres que consultan al ginecólogo presentan V (15). Afecta preferentemente a mujeres adultas, sin embargo también pueden padecer de V las niñas pre-adolescentes (16).…”

Section: Prevalenciaunclassified

Vulvodinia: Un Diagnóstico Olvidado Frente Al Dolor Vulvar

2010

Rev. chil. obstet. ginecol.

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RESUMENLa vulvodinia es una patología compleja y de difícil tratamiento. Se define como un dolor crónico de la vulva, que puede ser generalizado o localizado. La primera vez que se escribe sobre esta fue en 1889, por Skene. Sin embargo, es sólo hasta 1976, que los miembros de la International Society for Study of Vulvovaginal Diseases, reconocieron el dolor vulvar como una entidad patológica. Se estima una prevalencia de un 15%, con unas 14 millones de mujeres que lo padecen en EEUU. Generalmente consultan múltiples veces y a diferentes médicos, antes de llegar a un diagnóstico. No existen pruebas específicas, por lo que la clínica y el examen físico son las principales herramientas. Se deben excluir todas aquellas patologías que explican este dolor crónico vulvar. Su etiología es multifactorial, involucrando cambios a nivel de nociceptores, alteraciones de la inervación y la presencia de factores inflamatorios. Sin embargo, no podemos dejar de lado los aspectos psicosexuales, que pueden modular o desencadenar el dolor vulvar, al encontrar un sustrato alterado a nivel de estos tejidos. Basándose en estos aspectos, hoy existen diferentes tratamientos, que son efectivos si los utilizamos asociados y en forma gradual, ya que se potencian entre ellos. PALABRAS CLAVE: Dolor vulvar, vulvodinia, disestesia vulvar, dolor vulvar crónico, vestibulitis vulvar SUMMARYVulvodynia is a complex pathology and difficult to treat. In 1889 Skene was the first who write about this. However, only until 1976 the members of the International Society for Study of Vulvovaginal Diseases, recognized the vulvar pain as a disease entity. Prevalence estimated at 15% with an estimated 14 million women who suffer in the USA. A high number of gynaecologists do not know this diagnosis. For this reason women consult multiple times and to different doctors to reach a diagnosis. There are no specific tests for diagnosis. Finding in the clinical and physical examination are the main tools for this diagnosis. The different pathologies that could explain the presence of a chronic vulvar pain must be excluded. Undoubtedly its aetiology is multifactorial, involving changes in the number of nociceptors and alterations in the innervations, and the presence of inflammatory factors that may be the starting point of this pathology, as it seeks to explain the neuropathic theory. However we can not ignore the psychosomatic theory in explaining the psychosexual disorders as a trigger vulvar pain, in these altered tissues. Based on these aspects there are now treatments that are more or less effective when are gradually associated for better results.

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Vulvar vestibulitis: Prevalence and historic features in a general gynecologic practice population

Cited by 233 publications

References 4 publications

Sensory Neuropeptides, Serotonin Innervations and Personality in Women with Vulvodynia

Sensory Neuropeptides, Serotonin Innervations and Personality in Women with Vulvodynia

Assessment of vulvodynia symptoms in a sample of US women: a prevalence survey with a nested case control study

Vulvodinia: Un Diagnóstico Olvidado Frente Al Dolor Vulvar

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