VUp-Regulation of VCAN Promotes the Proliferation, Invasion and Migration and Serves as a Biomarker in Gastric Cancer [Corrigendum]

Abstract

OncoTargets and Therapy is an international, peer-reviewed, open access journal focusing on the pathological basis of all cancers, potential targets for therapy and treatment protocols employed to improve the management of cancer patients. The journal also focuses on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction. The manuscript management system is completely online and includes a very quick and fair peer-review system, which is all easy to use. Visit http://www.dovepress.com/ testimonials.php to read real quotes from published authors.

Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney

“…Studies have demonstrated that VCAN is upregulated in several tumors such as renal carcinoma, gastric cancer, pancreatic cancer, and colon cancer [33][34][35][36][37], and is expressed predominantly in cancer stroma rather than in epithelial components [36,37]. Our study found that VCAN was highly expressed in 96.88% of MTSCCs, which is consistent with previous findings [34,36]. The role of SOSTDC1 as a bone morphogenetic protein antagonist [38] in malignant tumors has not been fully clarified.…”

“…VCAN is one of the main components of the ECM, and plays an essential role in cell adhesion, proliferation, migration, and angiogenesis [31,32]. Studies have demonstrated that VCAN is upregulated in several tumors such as renal carcinoma, gastric cancer, pancreatic cancer, and colon cancer [33][34][35][36][37], and is expressed predominantly in cancer stroma rather than in epithelial components [36,37]. Our study found that VCAN was highly expressed in 96.88% of MTSCCs, which is consistent with previous findings [34,36].…”

RETRACTED: Cortactin contributes to the tumorigenesis of gastric cancer by activating ERK/MMP pathway

“…Gastric cancer (GC) is one of the most common malignant tumors in the world, with a poor prognosis and a severe threat to human health [ 1 ]. The primary method of diagnosis for GC is endoscopy and biopsy, which are invasive and expensive and can cause discomfort and anxiety to patients [ 2 ].…”

“…The primary method of diagnosis for GC is endoscopy and biopsy, which are invasive and expensive and can cause discomfort and anxiety to patients [ 2 ]. Radical gastrectomy remains the major method for the treatment of GC, but the diagnostic rate of early GC is less than 10%, which is mainly confirmed in the late stage of metastatic GC [ 1 , 3 , 4 ]. Accordingly, understanding the pathogenesis and identifying reliable prognostic biomarkers are urgent for effective treatment, which helps to improve the quality of life and survival of GC patients.…”

Significance of monocyte infiltration in patients with gastric cancer: A combined study based on single cell sequencing and TCGA

“…RGS2 is a multifunctional RGS protein that effectively interferes with signal transduction by coupling with Gqa receptors, thereby regulating multiple G protein-linked signaling pathways (53). VCAN is a chondroitin sulfate proteoglycan that affects cell adhesion, proliferation, migration and angiogenesis, and also participates in multiple pathological processes such as nervous system and circulatory system (54). CPVL may promote human tumor progression by inhibiting STAT1 pathway through interacting with BTK/p300 axis (55).…”