W. B. Yeats, W. J. Turner and Edmund Dulac: The Broadsides and Poetry Broadcasts

McKenna, Wayne

doi:10.1007/978-1-349-08861-4_14

Cited by 2 publications

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“…However, the frequency has been estimated to be as low as 1 in 5000 (5) and as high as 1 in 500 (6). The mortalities from HCM have been documented at 2-6% per year (7)(8)(9), and more than one-half are caused by sudden death (SD) (8,10,11). Prognosis of such SD is unpredictable, and a practical diagnosis and treatment have not been satisfactorily established.…”

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confidence: 99%

Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden‐death pigs with hypertrophic cardiomyopathy

Lee

Lin²,

Chiu³

et al. 1996

FASEB j.

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We recently developed a pig model with naturally occurring hypertrophic cardiomyopathy (HCM). To further characterize the biochemical features of high frequency of sudden death affected by this disease, the protein profiles of ventricular tissues were analyzed on normal, HCM, and HCM with sudden-death pigs. By sodium dodecylsulfate-polyacrylamide gel electrophoresis, a protein corresponding to an apparent molecular mass of 90 kDa (p90) was found to be markedly decreased in the HCM-affected tissues of sudden-death pigs, but not in HCM or normal pigs. Further study showed that the primary decrease of p90 in HCM pigs with sudden death was located mainly in the interventricular septum. As determined by the molecular mass and isoelectric point on 2-dimensional gels and Western immunoblot with a specific 90 kDa heat shock protein (HSP90) monoclonal antibody, the unknown protein was identified as HSP90. Our findings indicate for the first time that substantially decreased heart HSP90 is associated with HCM pigs with sudden death. Although the role that HSP90 may play in protecting pigs with HCM from sudden death is still nuclear, the model itself may provide further insight into understanding the role of heat shock proteins in cardiac sudden death.-Lee, W.-C., Lin, K.-Y., Chiu, Y.-T., Lin, J.-H., Cheng, H.-C., Huang, H.-C., Yang, P.-C., Liu, S.-K., Mao, S. J. T. Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden-death pigs with hypertrophic cardiomyopathy.

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confidence: 99%

Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden‐death pigs with hypertrophic cardiomyopathy

Lee

Lin²,

Chiu³

et al. 1996

FASEB j.

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“…[17] Coactivatorsa nd corepressors are strongly involvedi nt his process, and their different binding to the activatedc omplex may favor and repress, respectively,t arget gene transcription. [20,21] Ak ey role in the activation process is played by as ubstructure of the LBD, helix 12 (H12), located in the C-terminus portion of PPARs. Specific studies have indicated that H12 folding is responsible for the globale ffect of aP PARl igand.I np articular,c orrect folding of H12 (holo-apoc onformation)e nsures receptor activation,w hereas misfolding preventsb iological effects, so resulting in antagonisticb ehavior.…”

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confidence: 99%

The Anticancer Potential of Peroxisome Proliferator‐Activated Receptor Antagonists

et al. 2018

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The effects on cancer-cell proliferation and differentiation mediated by peroxisome proliferator-activated receptors (PPARs) have been widely studied, and pleiotropic outcomes in different cancer models and under different experimental conditions have been obtained. Interestingly, few studies report and little preclinical evidence supports the potential antitumor activity of PPAR antagonists. This review focuses on recent findings on the antitumor in vitro and in vivo effects observed for compounds able to inhibit the three PPAR subtypes in different tumor models, providing a rationale for the use of PPAR antagonists in the treatment of tumors expressing the corresponding receptors.

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W. B. Yeats, W. J. Turner and Edmund Dulac: The Broadsides and Poetry Broadcasts

Cited by 2 publications

References 0 publications

Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden‐death pigs with hypertrophic cardiomyopathy

Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden‐death pigs with hypertrophic cardiomyopathy

The Anticancer Potential of Peroxisome Proliferator‐Activated Receptor Antagonists

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