Here, we disclose a useful approach to novel tetrahedral building blocks containing N-heterocycles. Pyrrole was introduced in the tetraphenylmethane (TPM) core by employing the RCM strategy, Clauson-Kaas reaction, Paal- Knorr condensation and Ullman coupling as key steps. In addition, various heterocyclic derivatives of TPM were prepared using nickel catalysts. We also studied the photophysical properties of synthesized TPM derivatives containing different peripheral substituents and it was found that they possess high quantum yield.