W1152 A Novel Image Analysis Tool ‘MRI3D’ for Detailed Assessment of Gastrointestinal Structure in Three Dimensions

Banerjee, Sreerup; Fox, Mark; Schwizer, Werner; Fried, Michael; Pal, Anupam

doi:10.1016/s0016-5085(10)63046-6

Cited by 4 publications

(5 citation statements)

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“…Gastric volume was documented by MRI with a four‐channel phased‐array receive coil (1.5T Achieva, Philips Healthcare, Best, The Netherlands) at baseline, immediately after ingestion and repeated at 9, 15 and 30 min after ingestion of the test medication. Secondary outcomes, total gastric volume, gastric contents volume and the position of the intragastric Gaviscon (distinct contrast with gadolinium‐labelled liquid component of test meal) or Alucol (negative contrast due to the presence of aluminium) were measured at 15 min by the technicians [AP, RA] unaware of allocation using MRI3D (an image analysis software developed Matlab 7.4 Platform, The MathWorks Inc., Natick, MA, USA) …”

Section: Methodsmentioning

confidence: 99%

“…Secondary outcomes, total gastric volume, gastric contents volume and the position of the intragastric Gaviscon (distinct contrast with gadolinium-labelled liquid component of test meal) or Alucol (negative contrast due to the presence of aluminium) were measured at 15 min by the technicians [AP, RA] unaware of allocation using MRI3D (an image analysis software developed Matlab 7.4 Platform, The MathWorks Inc., Natick, MA, USA). 30 After 30 min, the subject was taken out of the scanner and samples of gastric content were obtained through the perfusion channel of the catheter from 10 cm below and 1 cm below OGJ. Gastric acidity was measured using universal pH indicator paper (Merck Millipore, Darmstadt, Germany).…”

Section: Mechanism Of Reflux Suppression Visualised By Mrimentioning

confidence: 99%

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Post‐prandial reflux suppression by a raft‐forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH‐impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double‐blind study in reflux patients

Sweis

Kaufman

Anggiansah

et al. 2013

Aliment Pharmacol Ther

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Section: Methodsmentioning

confidence: 99%

Section: Mechanism Of Reflux Suppression Visualised By Mrimentioning

confidence: 99%

Post‐prandial reflux suppression by a raft‐forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH‐impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double‐blind study in reflux patients

Sweis

Kaufman

Anggiansah

et al. 2013

Aliment Pharmacol Ther

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“…In total, 63 360 MR images were processed to generate 3D reconstructions by a semi-automatic image analysis system as described previously. 29,31 These 3D images of the stomach were then used to calculate total gastric volume (TGV), gastric air volume (AV), and gastric content volume (GCV), and segmental volumes (described later) at each time point during the study. The gastric axis was generated (described in the next section) to aid in dividing the stomach into different segments.…”

Section: Image Segmentation and 3d Reconstructionmentioning

confidence: 99%

“…The analyses detailed here requires segmentation and 3D reconstruction of the MR images, which was performed by an image analysis system developed by the authors (SB and AP) using the MATLAB coding platform (MATLAB ® , version 7.5.0.338 (R2007b), MathWorks Inc). 29,31 In the image analysis system, a set of virtual MR images was generated along arbitrary planes through the MR image stack such that they intersect the region of interest (ROI, ie, stomach) on a selected ("index") postprandial scan. These virtual images were segmented semi-automatically.…”

Section: A Ppen D I X I M Ag E a N A Lys I S S Ys Temmentioning

confidence: 99%

Volume and position change of the stomach during gastric accommodation and emptying: A detailed three‐dimensional morphological analysis based on MRI

Banerjee

Pal

Fox

2020

Neurogastroenterology Motil

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Background The proximal and distal regions of the stomach are thought to have different roles during gastric accommodation and emptying; however, regional changes in gastric structure and function during and after a meal have not been described in detail. This study applied non‐invasive imaging to study changes in regional gastric volume and morphology during accommodation and emptying of a liquid nutrient meal. Method MRI studies were performed on 16 healthy volunteers. Three‐dimensional (3D) gastric morphology was reconstructed by validated image processing technology. The 3D models were segmented into seven regions. The relative contribution of each region to gastric accommodation and emptying was assessed. Changes in morphology were documented by tracking movements of four distinct gastric landmarks. Key Results The initial 100 mL liquid nutrient increases distal stomach volume more than that of other gastric regions (∆V7 = 28 ± 6% ∆TGV; P ≤ .05). Subsequent volume is accommodated mainly in the proximal stomach (∆V1 = 42 ± 10% ∆TGV; P ≤ .05). Early‐phase emptying occurs from distal stomach with proximal stomach volume remaining stable. Subsequently, distal stomach volume remains stable while proximal stomach volume decreases progressively. During gastric filling, the stomach elongates and expands anteriorly and inferiorly (15.2 ± 7.4 mm and 32.3 ± 8.4 mm, respectively, for the incisural midpoint) with torsion indicated by ~70° difference in the movements of proximal and distal gastric landmarks. Conclusions and Inferences Non‐invasive MRI describes volume change and distribution of a liquid meal within proximal and distal stomach during gastric accommodation and emptying. Additionally, novel observations of changes to 3D gastric morphology within the abdomen are documented.

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“…3D Reconstruction Semiautomatic image segmentation, 3D reconstruction and subsequent geometric analyses were performed using a custom designed image analysis software 16 developed using Matlab ® 7.4 (The MathWorks Inc., Natick, MA, USA). Initially 5‐10 points were selected on the edges of the gastric lumen.…”

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confidence: 99%

The gastro‐esophageal reflux barrier: biophysical analysis on 3D models of anatomy from magnetic resonance imaging

Roy

Fox

Curcic

et al. 2012

Neurogastroenterology Motil

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Background The function and structure of the gastro‐esophageal junction (GEJ) determine its efficacy as a reflux barrier. This study presents a novel methodology for the quantitative assessment of GEJ and proximal gastric morphology from magnetic resonance (MR) imaging. Based on this data we propose a new conceptualization of the hypothesis that a flap valve mechanism contributes to reflux protection. Methods 3D models of the GEJ and proximal stomach were reconstructed from MR images in 12 healthy volunteers during respiration and on eating a test meal to maximum satiation. A rotating plane analysis measured the gastro‐esophageal insertion angle and span of contact. An ellipsoid fit provided quantitative assessment of gastric shape and orientation relative to a fixed anatomical reference point. Position of the esophageal insertion on the ‘gastric ellipse’ was noted. An ellipsoid‐cylinder model was designed to analyze the relationships among parameters describing the GEJ morphology. Key Results The insertion angle became more acute on expiration, but did not change with meal ingestion. In contrast the span of contact did not vary with respiration, but increased with gastric filling. Changes in gastric morphology with distension further augmented the span of gastro‐esophageal contact in almost 70% of the studies. Conclusions & Inferences Novel MR imaging and biophysical analysis of the GEJ and proximal stomach provide a quantitative description of structures contributing to the reflux barrier. Changes in these parameters during respiration and on eating support the hypothesis that structural components of a functional ‘flap valve’ like mechanism contribute to reflux protection.

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W1152 A Novel Image Analysis Tool ‘MRI3D’ for Detailed Assessment of Gastrointestinal Structure in Three Dimensions

Cited by 4 publications

References 0 publications

Post‐prandial reflux suppression by a raft‐forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH‐impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double‐blind study in reflux patients

Post‐prandial reflux suppression by a raft‐forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH‐impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double‐blind study in reflux patients

Volume and position change of the stomach during gastric accommodation and emptying: A detailed three‐dimensional morphological analysis based on MRI

The gastro‐esophageal reflux barrier: biophysical analysis on 3D models of anatomy from magnetic resonance imaging

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