W12-P-018 Lipid-peroxidation is enhanced in SLE patients and associated with arterial and renal disease manifestations

Lipidomics in autoimmune diseases with main focus on systemic lupus erythematosus

“…Dyslipoproteinemia deregulation was observed in SLE, namely by low levels of HDL cholesterol and elevated levels of both VLDL cholesterol and triglycerides (TG) [67]. Lupus patients also show increased concentrations of oxidized LDL and an anomalous chylomicron metabolism, which is consistent with the higher levels of 4-HNE [52,68,69]. Levels of oxidized LDL detected by the monoclonal antibody E06 are significantly higher in SLE patients and are associated with cardiovascular disease that develop in SLE [74,75].…”

“…Through multi-dimensional mass spectrometry-based shotgun lipidomics it was found an increase of the levels of 4-hydroxyalkenal species [52]. The elevation of 4hydroxyalkenals levels alongside with the upregulation of LPE and the increased levels of oxidized LDL mention above, are undoubtedly indicative of lipid peroxidation [52,68].…”

“…In spite of the lack of knowledge regarding the variation of the lipid profile at a molecular level in SLE, there is evidence that lipid metabolism suffers alterations namely in lipoprotein metabolism during the course of SLE disease [52,[66][67][68][69][70][71][72][73].…”