W2070 Biomagnetic Signatures of Diabetic Gastroparesis

Bradshaw, Leonard A.; Obioha, Chike B.; Chung, E. C. H.; Erickson, J. Alan; Richards, William O.

doi:10.1016/s0016-5085(09)63627-1

Cited by 2 publications

(1 citation statement)

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“…ICCs are electrically coupled by gap junctions to longitudinal and circular muscle layers and the electrical activity propagates passively through these layers (Thuneberg 1982, Ordog et al 1999. Motility disorders of the stomach such as gastroparesis and functional dyspepsia are known to alter spatiotemporal parameters of the gastric slow wave activity (Lin and Chen 2001, Bradshaw et al 2009c, 2011. Most electromyographic techniques for detecting gastric slow wave activity have either involved placing serosal electrodes on to the surface of the stomach during an abdominal surgery or attaching intraluminal electrodes to the mucosa of the stomach (Chen et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Effects of body mass index on gastric slow wave: a magnetogastrographic study

et al. 2014

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We measured gastric slow wave activity simultaneously with magnetogastrogram (MGG), mucosal electromyogram (EMG) and electrogastrogram (EGG) in human subjects with varying body mass index (BMI) before and after a meal. In order to investigate the effect of BMI on gastric slow wave parameters, each subject’s BMI was calculated and divided into two groups: subjects with BMI ≤ 27 and BMI > 27. Signals were processed with Fourier spectral analysis and Second-Order Blind Identification (SOBI) techniques. Our results showed that increased BMI does not affect signal characteristics such as frequency and amplitude of EMG and MGG. Comparison of the postprandial EGG power, on the other hand, showed a statistically significant reduction in subjects with BMI > 27 compared with BMI ≤ 27. In addition to the frequency and amplitude, the use of SOBI-computed propagation maps from MGG data allowed us to visualize the propagating slow wave and compute the propagation velocity in both BMI groups. No significant change in velocity with increasing BMI or meal was observed in our study. In conclusion, multichannel MGG provides assessment of frequency, amplitude and propagation velocity of the slow wave in subjects with differing BMI categories and were observed to be independent of BMI.

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Section: Introductionmentioning

confidence: 99%

Effects of body mass index on gastric slow wave: a magnetogastrographic study

et al. 2014

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Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea

Somarajan

Muszynski

Olson

et al. 2022

American Journal of Physiology-Gastrointestinal and Liver Physi

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Chronic nausea is a widespread functional disease in children with numerous comorbidities. High resolution electrogastrogram (HR-EGG) has shown sufficient sensitivity as a non-invasive clinical marker to objectively detect distinct gastric slow wave properties in children with functional nausea. We hypothesized that the increased precision of magnetogastrogram (MGG) slow wave recordings could provide supplementary information not evident on HR-EGG. We evaluated simultaneous pre- and postprandial MGG and HR-EGG recordings in pediatric chronic nausea patients and healthy asymptomatic subjects, while also measuring nausea intensity and nausea severity. We found significant reductions in postprandial dominant frequency and normogastric power, and higher levels of postprandial bradygastric power in nausea patients in both MGG and HR-EGG. MGG also detected significantly lower preprandial normogastric power in patients. A significant difference in the mean preprandial gastric slow wave propagation direction was observed in patients as compared to controls in both MGG (control: 180°±61°, patient: 34°±72°; p ˂ 0.05) and HR-EGG (control: 240°±39°, patient: 180°±46°; p ˂ 0.05). Patients also showed a significant change in the mean slow wave direction between pre- and postprandial periods in MGG (p ˂ 0.05). No statistical differences were observed in propagation speed between healthy subjects and patients in either MGG or HR-EGG pre/postprandial periods. The use of MGG and/or HR-EGG represents an opportunity to assess noninvasively the effects of chronic nausea on gastric slow wave activity. MGG data may offer the opportunity for further refinement of the more portable and economical HR-EGG in future machine-learning modeling of functional nausea.

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W2070 Biomagnetic Signatures of Diabetic Gastroparesis

Cited by 2 publications

References 0 publications

Effects of body mass index on gastric slow wave: a magnetogastrographic study

Effects of body mass index on gastric slow wave: a magnetogastrographic study

Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea

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