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Abstract

We evaluated the efficiency of perfusion with olifen in preventing oxidative stress at the early stage of acute pancreatitis. Transaortic perfusion with olifen prevented clinical and biochemical symptoms of acute pancreatitis, attenuated oxidative stress, reduced peritoneal exudation, and restricts the area of pancreatic necrosis to 6% tissue.

Ultrasonic model of acute pancreatitis

“…Patients with acute pancreatitis constitute 5-10% of all surgical inpatients, and this patient population is still increasing [3,5]. Acute pancreatitis is a necrotic condition with the development of severe toxemic and septic complications [1] requiring timely treatment [4]. Several experimental models of acute pancreatitis are known, which do not fully correspond to clinically observed structural and functional metabolic manifestations of pancreonecrosis.…”