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Abstract

The study was aimed to investigate the activity of hydroalcoholic extract of Cucumis sativus in gastric ulcerated rats. Anti ulcer activity was evaluated via oral administration of HACS at the dose 250, 500 and 1000mg/kg thrice in a day for 5 days before pyloric ligation ulceration, indomethacin and ethanol induced ulceration. Various parameters such as ulcer index, gastric volume, pH of gastric juice, total acidity, estimation of total proteins, total carbohydrates, total hexoses, hexosamine, fucose, salic acid and histopathological parameters were studied in the control group and pretreated groups with hydroalcoholic extract of fruit pulp of Cucumis sativus and standard drug ranitidine. In indomethacin, ethanol and pyloric ligation model, the pretreatment with HACS and ranitidine significantly reduce the ulcer index, free acidity as compared with controlled group. The % protection of ulcers were evaluated. The extract showed significantly (P<0.05) increase in pH with significant decrease in volume of gastric juice, free and total acidity. Histopathological findings also confirm the antiulcer activity of Cucumis sativus fruit pulp extract in albino wistar rats. The present study showed that HACS have anti ulcer activity in 3 models. INTRODUCTION: Gastric ulcers are very common disease human suffering today, it is a localised loss of gastric as well as duodenal mucosa. Peptic ulcer mainly seen in the path of GIT tract which is exposed to gastric acid and secretion, mainly 2 types of ulcers are peptic ulcer and duodenal ulcer. The major factors lead to ulcer is infection with gram negative, helicobacter pylori, increased HCl secretion inadequate mucosal defense against gastric acid. The peptic ulcers occurs due to imbalance between aggressive (acid, pepsin, bile, H. Pylori) and defensive factor (prostaglandin, bicarbonate secretion, etc.) 1 .