Wachstumshormontherapie beim Erwachsenen

Abstract

In adult patients with growth hormone deficiency due to organic hypopituitarism, substitution with growth hormone is very useful and well established. Positive influence on numerous target parameters has been investigated in randomised controlled trials (evidence level I) and could be documented. Thus, growth hormone substitution in hypopituitarism is scientifically founded and has been admitted by the authorities in the European Union. Concerning pharmacotherapy with growth hormone in healthy elderly persons without pituitary disease and also doping in sports, the situation is completely different. Use of growth hormone in these circumstances has not sufficiently been investigated concerning indications, efficacy and safety. Ethical and economical aspects have not been evaluated yet. Serious concerns about the therapeutic safety need to be considered.

Interdental Spacing and Orthodontic Treatment in Competitive Athletes: Clues to Doping with Growth Hormones?

“…Ein weiteres in diesen Sportarten verbreitetes Dopingmittel ist das gentechnisch hergestellte rekombinante menschliche Wachstumshormon (rhGH; natürlich vorkommend als hGH -human growth hormone -, Somatotropin oder somatotropes Hormon bezeichnet). Dieses Peptidhormon ist medizinisch vor allem bei der organisch bedingten Hypophysenvorderlappen-Insuffizienz indiziert, die mit Wachstumshormonmangel einhergeht [3,12]. Im Sport wird rhGH seit Anfang der 1980er Jahre missbräuchlich eingesetzt, da ihm ebenfalls eine muskelauf-und fettabbauende Wirkung zugeschrieben wird [16,20].…”

“…Another drug widely used in these sports is recombinant human growth hormone produced by gene technology (rhGH; naturally occurring as hGH -human growth hormone -, also known as somatotropin or somatotropic hormone). In a medical context, the main indication for using this peptide hormone is to treat anterior pituitary insufficiency of organic origin involving growth hormone deficiency [3,12]. rhGH has been misused in sports since the early 1980s because a muscle-building and fat-destroying (lipocatabolic) effect has been attributed to it [16,20].…”