Waddlia: An emerging pathogen and a model organism to study the biology of chlamydiae

Lamoth, Frédéric; Pillonel, Trestan; Greub, Gilbert

doi:10.1016/j.micinf.2015.09.021

Cited by 12 publications

(17 citation statements)

References 51 publications

(64 reference statements)

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“…Future investigations should provide new opportunity to delineate the function of glycogen in chlamydiae especially with the development of forward genetic approaches 52,53 . Finally, the use of GlgE inhibitors initially designed against mycobacterial infections and to some extent the use of inhibitors of chlamydial glycogenmetabolizing enzymes might define new attractive drugs to treat W. chondrophila, since this Chlamydia-related bacteria has been increasingly recognized as a human pathogen 54,55 .…”

Section: Discussionmentioning

confidence: 99%

Conservation of the glycogen metabolism pathway underlines a pivotal function of storage polysaccharides in Chlamydiae

et al. 2021

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The order Chlamydiales includes obligate intracellular pathogens capable of infecting mammals, fishes and amoeba. Unlike other intracellular bacteria for which intracellular adaptation led to the loss of glycogen metabolism pathway, all chlamydial families maintained the nucleotide-sugar dependent glycogen metabolism pathway i.e. the GlgC-pathway with the notable exception of both Criblamydiaceae and Waddliaceae families. Through detailed genome analysis and biochemical investigations, we have shown that genome rearrangement events have resulted in a defective GlgC-pathway and more importantly we have evidenced a distinct trehalose-dependent GlgE-pathway in both Criblamydiaceae and Waddliaceae families. Altogether, this study strongly indicates that the glycogen metabolism is retained in all Chlamydiales without exception, highlighting the pivotal function of storage polysaccharides, which has been underestimated to date. We propose that glycogen degradation is a mandatory process for fueling essential metabolic pathways that ensure the survival and virulence of extracellular forms i.e. elementary bodies of Chlamydiales.

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Section: Discussionmentioning

confidence: 99%

Conservation of the glycogen metabolism pathway underlines a pivotal function of storage polysaccharides in Chlamydiae

et al. 2021

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“…The current study and the previous study by Verweij et al show that the W. chondrophila seroprevalence was similar in both the TFI+ and TFI− group. Although these two studies are the only ones investigating the role of W. chondrophila in the development of TFI, other studies were published that investigated the role of W. chondrophila in other female reproductive health problems (reviewed in [19,29]). In two studies performed by Baud et al, the role of W. chondrophila was examined in women with (recurrent) miscarriages or uneventful pregnancies [12,14].…”

Section: Discussionmentioning

confidence: 99%

Screening of Chlamydia trachomatis and Waddlia chondrophila Antibodies in Women with Tubal Factor Infertility

et al. 2020

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Waddlia chondrophila is an emerging intracellular pathogen belonging to the order of Chlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both W. chondrophila and Chlamydia trachomatis IgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI−) or TFI-positive (TFI+). The total seroprevalence was 13.4% for C. trachomatis and 38.8% for W. chondrophila. C. trachomatis antibodies were present significantly more often in the TFI+ group than in the TFI− group, while for W. chondrophila no difference could be observed. In conclusion, our study confirms the association between C. trachomatis seropositivity and TFI, but no association was found between W. chondrophila seropositivity and TFI. The high percentage of W. chondrophila seropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on this Chlamydia-like bacterium and its possible role in infertility.

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“…Stąd przyjmuje się, że cysty -formy spoczynkowe ameb, stanowią bardzo duże zagrożenie dla człowieka i zwierząt ze względu na wspomniane już ich powszechne występowanie w wodzie, w tym w osadach zbiorników wody słodkiej i słonej oraz wodzie wodociągowej, mineralnej i w systemach wodnych jednostek stomatologicznych, a nawet w urządzeniach klimatyzacyjnych i w aparatach do dializ, a także w glebie i powietrzu (kurz) [41,58]. Wykazano, że endosymbiontami ameb w szczegól ności są gatunki z rodziny Parachlamydiaceae [11,15,29,30,32,34,41,62] oraz Simkania negevensis z rodziny Simka niaceae [45,59], a także Waddlia chondrophila z rodziny Waddliaceae, której namnażanie się w amebach wykazano in vitro [57]. Znane są poglądy mówiące, że być może te właśnie wolno żyjące ameby przyczyniły się do ewolucji chlamydii, nim nastąpiła ich ekspansja do wielokomórkowych gospodarzy, w tym ludzi i zwierząt [75,92].…”

Section: Wstępunclassified

“…Po raz pierwszy W. chon drophila wyizolowano z poronionych płodów bydła [24], zaś W. malaysiensis otrzymano z odchodów nietoperzy owocowych z gatunku Eonycteris spelaea żyjących w Malezji [4,13], natomiast W. cocoyoc izolowano z płuc nietoperzy owocowych z gatunku Artibeus inter medium żyjących w Meksyku [71]. U ludzi W. chondrophila jest przyczyną infekcji układu rodnego, co skutkuje poronieniami [2,4,6,20,57,78], gdyż bytując wewnątrzkomórkowo, ma możliwość utrzymywania się w komórkach łożyska [20]. Bakteria ta infekuje głównie komórki nabłonka gruczołowego dróg rodnych, powodując poronienia manifestujące się zapaleniem błony doczesnej, błon płodowych i powoduje zwiększenie ilości komórek plazmatycznych we krwi [6].…”

Section: Chorobotwórczość Rodziny Waddliaceaeunclassified

Pathogenicity of environmental chlamydiae for humans and animals

Pawlikowska-Warych

Palma

Deptuła

2017

Postępy Mikrobiologii - Advancements of Microbiology

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More and more attention has been paid to environmental chlamydiae in recent years. They were classified as pathogenic bacteria for both humans and animals. Thanks to molecular biology techniques, the following nine families of environmental chlamydiae were assigned to the order of Chlamydiales: Candidatus Clavichlamydiaceae, Criblamydiaceae, Parachlamydiaceae, Candidatus Piscichlamydiaceae, Rhabdochlamydiaceae, Simkaniaceae, Waddliaceae, Candidatus Actinochlamydiacae and Candidatus Parilichlamydiaceae. These bacteria are considered the infectious factors of zoonoses due to the fact that they can be found among pets and livestock such as cats, guinea pigs, sheep, cattle, and even fish. Many of these animals also suffer from diseases caused by these bacteria. In this study, while characterizing environmental chlamydiae, special attention has been paid to illnesses of the respiratory tract caused by Simkania negevensis, and to the abortions among people and ruminants caused by Waddlia chondrophila. Furthermore, the species of the Rhabdochlamydiaceae family , as well as the bacteria from the Parachlamydiaceae family responsible for eye illnesses in humans and animals, are also characterized in this work. Lastly, newly discovered fish chlamydiae, which are potential factors of illnesses in humans and terrestial animals, are also presented in this paper.

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Waddlia: An emerging pathogen and a model organism to study the biology of chlamydiae

Cited by 12 publications

References 51 publications

Conservation of the glycogen metabolism pathway underlines a pivotal function of storage polysaccharides in Chlamydiae

Conservation of the glycogen metabolism pathway underlines a pivotal function of storage polysaccharides in Chlamydiae

Screening of Chlamydia trachomatis and Waddlia chondrophila Antibodies in Women with Tubal Factor Infertility

Pathogenicity of environmental chlamydiae for humans and animals

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