Waist circumference alone predicts insulin resistance as good as the metabolic syndrome in elderly women

Nilsson, Göran; Hedberg, Pär; Jonason, Tommy; Lönnberg, Ingemar; Tenerz, Åke; Forberg, Rosanne; Öhrvik, John

doi:10.1016/j.ejim.2008.01.018

Cited by 28 publications

(27 citation statements)

References 27 publications

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“…On the other hand, RBP4 was not associated with other parameters of adiposity, IR indices, blood pressure, glucose or lipid metabolism. The association of RBP4 with waist circumference suggests that this adipokine could be related to abdominal AT mass (subcutaneous and visceral AT), which has been strongly associated with metabolic disorders, including IR (20). The lack of relationship between circulating RBP4 levels and indices of IR was reported by us in a previous study (11), and is in agreement with several scientific reports (12-14, 21, 22), but not with others (7-10).…”

Section: Discussionsupporting

confidence: 81%

Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects

Broch

Auguet²,

Ramírez³

et al. 2009

European Journal of Endocrinology

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Context and objective: Adipokines are involved in the etiopathology of obesity-related disorders. Since the role of adipokine retinol-binding protein-4 (RBP4) in obesity remains uncertain and its relationship with other adipokines and inflammatory markers has not been examined in detail, we investigated the relationships of RBP4 mRNA expression and circulating protein levels with obesity, anthropometric and metabolic variables, as well as with obesity-related inflammatory markers adiponectin and C-reactive protein. Subjects and methods:One-hundred and twenty-five subjects participated, 36 lean (body mass index (BMI): !25 kg/m 2 ) and 89 obese (overweight/obese; BMI: R25!40) whose anthropometric and metabolic variables were assessed. mRNA expression was quantified by real-time PCR in subcutaneous adipose tissue (s.c.-AT) of 46 subjects. Results: There was a tendency for circulating RBP4 levels to positively correlate with waist circumference (bZ0.29, PZ0.08; R 2 Z0.08), but there was no significant association with the obesity-related parameters analysed. RBP4 and adiponectin mRNA expression levels were similarly downregulated in the s.c.-AT of obese subjects (0.5-fold); however, RBP4 downregulation did not affect its circulating protein levels. The expression of RBP4 and adiponectin was positively correlated even after controlling for confounding factors (bZ0.59, P!0.0001; R 2 Z0.40). Conclusions: In our population, RBP4 circulating levels were not significantly correlated with obesityrelated parameters, although a tendency to correlate with waist circumference suggests a relationship with insulin resistance and other metabolic disorders. In addition, our results suggest that the production of RBP4 by other tissues such as liver, rather than s.c.-AT, may be involved in regulating RBP4 circulating levels.

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Section: Discussionsupporting

confidence: 81%

Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects

Broch

Auguet²,

Ramírez³

et al. 2009

European Journal of Endocrinology

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“…In addition, it has been found that the mean systolic blood pressure and diastolic blood pressure, fasting glucose, HDL-c, LDL-c and total cholesterol were lower than observed in other studies [7,12,15]. However, the concentration of triglycerides was lower in those studies as compared to the present work.…”

Section: Discussioncontrasting

confidence: 56%

“…Besides these classical measurements and derived indices, different studies have proposed and used percentage of body fat (%BF), body fat (BF) and skinfolds (SF) as indicators of adiposity in the elderly [1,6,7,8,9,10,11,12,13,14,15]. A limited number of studies have sought to establish the relationship between BF and anthropometric /body composition in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Classic Anthropometric and Body Composition Indicators Can Predict Risk of Metabolic Syndrome in Elderly

et al. 2012

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Background/Aims: Although a variety of classical body measurements have been used to assess adiposity, it is still uncertain which is the best indicator to predict effects arising from the accumulation of body fat (BF) in the elderly. The objective of this study was to analyze different classical anthropometric and body composition measurements and their potential for predicting metabolic syndrome (MS) in elderly women. Methods: There were 113 women (60–83 years old) participating in the study, all of whom had their anthropometric, biochemical, hemodynamic and health conditions evaluated. Statistical analysis consisted of correlation coefficient and receiver operating characteristic (ROC) curves, and calculation of the area under the curve. Results: The waist-hip ratio (WHR) and waist circumference correlated with three (hyperglycemia, hypertriglyceridemia and low concentrations of high density lipoprotein-cholesterol) of the seven cardiometabolic risk factors studied. Body mass index, BF, percentage of BF, and the sum of skinfolds were less related to metabolic risk factors. Among the indicators used to characterize central adiposity, WHR was the index that showed the greatest area under the ROC curve. Conclusions: It is suggested that the WHR, an indicator of abdominal adiposity, should be incorporated into the identification of risk of MS in elderly women.

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“…24 The investigators reported that the optimal WC cutoff for insulin resistance estimated by HOMA-IR in these women was 88 cm. Women with WC > 88 cm had a relative risk of 5.6 of being insulinresistant compared to those with WC 88 cm in their study.…”

Section: Discussionmentioning

confidence: 99%

Clinical and biochemical indicators of homeostasis model assessment-estimated insulin resistance in postmenopausal women

Lin

Liou

Hsiao

et al. 2011

Journal of the Chinese Medical Association

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Postmenopausal women with HOMA-IR-estimated insulin resistance were at high risk of glucose abnormalities in this study. High HOMA-IR values were significantly associated with six clinical and biochemical indicators. Among these, high serum uric acid levels seemed to be a useful marker identifying postmenopausal women with insulin resistance. This study was registered at clinicaltrials.gov as NCT00945271.

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Waist circumference alone predicts insulin resistance as good as the metabolic syndrome in elderly women

Cited by 28 publications

References 27 publications

Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects

Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects

Classic Anthropometric and Body Composition Indicators Can Predict Risk of Metabolic Syndrome in Elderly

Clinical and biochemical indicators of homeostasis model assessment-estimated insulin resistance in postmenopausal women

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