Waist Circumference and Cardiovascular Risk Factors in Japanese Men and Women

Yoshida, Daigo; Toyomura, Kengo; Ueda, Naoyuki; Ohnaka, Keizo; Adachi, Masahiro; Takayanagi, Ryoichi; Kono, Suminori

doi:10.5551/jat.no539

Cited by 9 publications

(9 citation statements)

References 33 publications

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“…The results showed that overweight/obesity and abdominal obesity were associated with increased risks of CVD and DM in this young and middle-aged population. Other studies have also shown that BMI and/or WC were strongly linked to CVD and diabetes (Rexrode et al, 1998;Balkau et al, 2007b;Christian et al, 2009;Yoshida et al, 2009). However, the pathophysiological mechanism of this association was uncertain.…”

Section: Discussionmentioning

confidence: 99%

Body mass index, waist circumference, and cardiometabolic risk factors in young and middle-aged Chinese women

Xiao

Song

Zhao

et al. 2010

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To assess the associations between body mass index (BMI), waist circumference (WC), and cardiometabolic risk factors in young and middle-aged Chinese women. Methods: A total of 3011 women (1938 young women, 1073 middle-aged women), who visited our health care center for a related health checkup, were eligible for study. BMI and WC were measured. The subjects were divided into normal and overweight/obesity groups based on BMI, and normal and abdominal obesity groups based on WC. Cardiometabolic variables included triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), and blood pressure (BP). Results: The prevalence of overweight/obesity was significantly higher in middle-aged women (32.4%) than in young women (12.0%). The prevalence of abdominal obesity was also higher in middle-aged women (60.3%) than in young women (36.2%). There were significant differences in the comparison of all related cardiometabolic variables between different BMI (or WC) categories in young and middleaged women groups, respectively. After adjustment for age, partial correlation analysis indicated that both BMI and WC were correlated significantly with all related cardiometabolic variables. After adjustment for age and WC, although the correlation coefficient r′ was attenuated, BMI was still correlated significantly with all related cardiometabolic variables in young and middle-aged women. After adjustment for age and BMI, partial correlation analysis showed that WC was correlated significantly with TG, FBG, HOMA-IR, and HDL-C in young women and significantly with TG, HOMA-IR, and HDL-C in middle-aged women. Conclusions: The prevalence of overweight/obesity and abdominal obesity was high in Chinese young and middle-aged women. BMI was a better predictor of cardiovascular disease and diabetes than WC in young and middle-aged women, and moreover, measurement of both WC and BMI may be a better predictor of cardiovascular disease and diabetes mellitus than BMI or WC alone.

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Section: Discussionmentioning

confidence: 99%

Body mass index, waist circumference, and cardiometabolic risk factors in young and middle-aged Chinese women

Xiao

Song

Zhao

et al. 2010

J. Zhejiang Univ. Sci. B

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“…For the present study, 192 nondiabetic men were randomly selected. For the replication cohort in our examination of the association between DNAm levels and SNPs, we used samples from the general population-based Fukuoka cohort study [26,27], with 287 participants (136 men, 151 women) being randomly selected. Detailed information on each cohort is provided in the electronic supplementary material (ESM) Methods, and the characteristics of the participants are shown in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites

et al. 2015

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Aims/hypothesis To investigate epigenetic regulation of the plasma concentration of resistin, we performed an epigenomewide association study for this variable and DNA methylation (DNAm) in an elderly Japanese cohort and then assessed the relation of single nucleotide polymorphisms (SNPs) associated with the plasma resistin concentration to DNAm level at identified sites. Methods The association of plasma resistin level with DNAm status was examined in 191 nondiabetic elderly men with the Illumina Infinium HumanMethylation450 BeadChip array. The association between DNAm status at specific sites in the flanking region of the resistin gene (RETN) and RETN mRNA abundance was then evaluated with a public data set for 1202 monocyte samples from a multi-ethnic cohort. Finally, the association of DNAm status and SNPs in the promoter region of RETN was assessed in two cohorts comprising a total of 478 Japanese individuals.Results DNAm status at cg02346997 located in the RETN promoter region showed a negative genome-wide significant association with the plasma resistin level (p=6.02×10 −10 ). Four DNAm sites in the RETN promoter region including cg02346997 (p=4.23×10 −70 ) showed a negative genome-wide significant association with RETN mRNA abundance in monocytes. Furthermore, the number of minor alleles of the RETN promoter SNPs rs34861192 and rs3219175 was negatively associated with DNAm level at cg02346997 (p=4.43×10 −17 ). Conclusions/interpretation Our results suggest that RETN promoter SNPs might influence the circulating resistin level through an effect on DNAm at cg02346997 and on RETN mRNA abundance in monocytes.

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“…PBCs were obtained from 192 participants of a baseline survey of the general population from a Fukuoka-based cohort study [7, 8]. This study was performed in accordance with the principles of the Declaration of Helsinki and was approved by the Institutional Review Board at Kyushu University.…”

Section: Methodsmentioning

confidence: 99%

Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines

et al. 2017

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BackgroundEpidemiological studies of DNA methylation profiles may uncover the molecular mechanisms through which genetic and environmental factors contribute to the risk of multifactorial diseases. There are two types of commonly used DNA bioresources, peripheral blood cells (PBCs) and EBV-transformed lymphoblastoid cell lines (LCLs), which are available for genetic epidemiological studies. Therefore, to extend our knowledge of the difference in DNA methylation status between LCLs and PBCs is important in human population studies that use these DNA sources to elucidate the epigenetic risks for multifactorial diseases. We analyzed the methylation status of the autosomes for 192 and 92 DNA samples that were obtained from PBCs and LCLs, respectively, using a human methylation 450 K array. After excluding SNP-associated methylation sites and low-call sites, 400,240 sites were subjected to analysis using a generalized linear model with cell type, sex, and age as the independent variables.ResultsWe found that the large proportion of sites showed lower methylation levels in LCLs compared with PBCs, which is consistent with previous reports. We also found that significantly different methylation sites tend to be located on the outside of the CpG island and in a region relatively far from the transcription start site. Additionally, we observed that the methylation change of the sites in the low-CpG promoter region was remarkable. Finally, it was shown that the correlation between the chronological age and ageing-associated methylation sites in ELOVL2 and FHL2 in the LCLs was weaker than that in the PBCs.ConclusionsThe methylation levels of highly methylated sites of the low-CpG-density promoters in PBCs decreased in the LCLs, suggesting that the methylation sites located in low-CpG-density promoters could be sensitive to demethylation in LCLs. Despite being generated from a single cell type, LCLs may not always be a proxy for DNA from PBCs in studies of epigenome-wide analysis attempting to elucidate the role of epigenetic change in disease risks.Electronic supplementary materialThe online version of this article (doi:10.1186/s40246-017-0106-6) contains supplementary material, which is available to authorized users.

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Waist Circumference and Cardiovascular Risk Factors in Japanese Men and Women

Cited by 9 publications

References 33 publications

Body mass index, waist circumference, and cardiometabolic risk factors in young and middle-aged Chinese women

Body mass index, waist circumference, and cardiometabolic risk factors in young and middle-aged Chinese women

Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites

Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines

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