Waist circumference is correlated with poorer cognition in elderly type 2 diabetes women

West, Rebecca; Ravona‐Springer, Ramit; Heymann, Anthony; Schmeidler, James; LeRoith, Derek; Koifman, Keren; D’Arcy, Ryan C.N.; Song, Xiaowei; Guerrero‐Berroa, Elizabeth; Preiss, Rachel; Hoffman, Hadas; Sano, Mary; Silverman, Jeremy M.; Schnaider‐Beeri, Michal

doi:10.1016/j.jalz.2016.03.017

Cited by 27 publications

(21 citation statements)

References 21 publications

(29 reference statements)

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“…Other pathways may operate in the subjective age-dementia link. For example, an older subjective age is also associated with higher systemic inflammation (Stephan et al, 2015a), greater metabolic dysregulation and lower pulmonary function (Stephan et al, 2015b) that contribute to higher dementia risk (Heneka et al, 2015; Vidal et al, 2013; West et al, 2016). In addition, individuals who feel older are more vulnerable to stress (Shrira et al, 2016), which amplifies the likelihood of cognitive impairment and dementia (Mah et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Subjective age and risk of incident dementia: Evidence from the National Health and Aging Trends survey

Stéphan¹,

Sutin

Luchetti

et al. 2018

Journal of Psychiatric Research

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The present study examines the association between subjective age and risk of incident dementia in a large longitudinal sample of older adults. Participants were adults aged 65 years and older from the National Health and Aging Trends Study (NHATS). Subjective age, covariates, and cognitive status were assessed in 2011 and cognitive status was again assessed in 2012, 2013, 2014 and 2015. Incident dementia was determined based on answers from self and proxy respondents. The analyses included 4,262 participants without dementia at baseline. Adjusting for demographic factors and baseline cognition, an older subjective age was related to higher likelihood of incident dementia. This association was partly accounted by depressive symptoms. Beyond the effect of chronological age, feeling older is associated with the risk of incident dementia.

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Section: Discussionmentioning

confidence: 99%

Subjective age and risk of incident dementia: Evidence from the National Health and Aging Trends survey

Stéphan¹,

Sutin

Luchetti

et al. 2018

Journal of Psychiatric Research

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“…Abbatecola et al showed that central adiposity, represented by WC, predicted an increased risk for cognitive decline during a 2‐year follow‐up period in older patients with diabetes. Recently, West et al reported that WC was correlated with lower overall cognition and executive performance in older women with type 2 diabetes. However, there has been no large‐scale cohort study to examine the association of late‐life WC with the incidence of dementia in an older population.…”

Section: Introductionmentioning

confidence: 99%

Association Between Waist Circumference and Dementia in Older Persons: A Nationwide Population‐Based Study

Cho

Hwang

Lee

et al. 2019

Obesity

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Objective This study examined whether a positive association exists between waist circumference (WC) and dementia among older persons. Methods The study population comprised 872,082 participants aged 65 years and older who participated in a Korean national health screening examination between January 1, 2009, and December 31, 2009. Adjusted hazard ratios and 95% CIs for dementia during follow‐up from 2009 to 2015 were calculated according to baseline BMI and WC categories. Results After a multivariate adjustment that included BMI, the hazard ratios for dementia showed a stepwise increase according to the increase in WC categories by 5 cm from 85 to 90 cm in men and from 80 to 85 cm in women until ≥ 110 cm (from 1.06 [95% CI: 1.03‐1.09] to 1.64 [95% CI: 1.37‐1.94] in men and from 1.04 [95% CI: 1.02‐1.07] to 1.58 [95% CI: 1.36‐1.84] in women). The influence of the current WC category for abdominal obesity on the risk of dementia was different according to BMI; especially, the normal weight men and women with abdominal obesity had a prominent increased risk of dementia compared with those without abdominal obesity. Conclusions Abdominal obesity, as measured by WC, was associated with significantly increased risk of dementia after adjustment for general obesity.

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“…There is limited information pertaining to the contribution of central obesity to cognitive dysfunction in T2DM. Traditional measures of central obesity, namely waist circumference (WC) and waist:hip ratio (WHR), were found to be associated with diminished cognitive performance in older individuals with T2DM . Whether the relationship between central obesity and cognition differs with the degree of general obesity remains unelucidated.…”

Section: Introductionmentioning

confidence: 99%

“…Traditional measures of central obesity, namely waist circumference (WC) and waist:hip ratio (WHR), were found to be associated with diminished cognitive performance in older individuals with T2DM. 9,11 Whether the relationship between central obesity and cognition differs with the degree of general obesity remains unelucidated. In this cross-sectional observational study, we evaluated the association of several traditional and novel measures of central obesity with cognitive function in non-demented multi-ethnic Asians with T2DM, including a stratified analysis by BMI.…”

Section: Introductionmentioning

confidence: 99%

Association of traditional and novel measures of central obesity with cognitive performance in older multi‐ethnic Asians with type 2 diabetes

Moh

Low

et al. 2020

Clinical Obesity

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Summary Literature evaluating the relationship between central obesity and cognitive deficits in type 2 diabetes (T2DM) remains scarce. This cross‐sectional analysis explored the association of novel and traditional central obesity measures with cognitive performance in older (aged ≥60 years) non‐demented multi‐ethnic Asians with T2DM, including a stratified analysis by body mass index (BMI). Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status. Central obesity measures including visceral fat area (VFA), waist circumference, waist:hip ratio, waist:height ratio, abdominal volume index, body roundness index and conicity index were measured and/or computed. In our cohort (N = 677; mean age = 67 ± 5 years, 51.7% men), VFA emerged as an associate of overall cognitive performance after covariate adjustment and Bonferroni correction (β = −.10, 95% CI = −0.18, −0.03), outperforming the other adiposity indices. Specifically, VFA was inversely associated with delayed memory and language scores. Additionally, compared with normal‐weight individuals, excess visceral obesity (VFA ≥100 cm2) was independently associated with lower cognitive scores to a greater extent in normal BMI (<23 kg/m2) adults than in those with high BMI (≥23 kg/m2). Assessment and management of visceral adiposity may help to prevent cognitive decline in older people with T2DM, and reduce the global burden of dementia in ageing populations.

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Waist circumference is correlated with poorer cognition in elderly type 2 diabetes women

Cited by 27 publications

References 21 publications

Subjective age and risk of incident dementia: Evidence from the National Health and Aging Trends survey

Subjective age and risk of incident dementia: Evidence from the National Health and Aging Trends survey

Association Between Waist Circumference and Dementia in Older Persons: A Nationwide Population‐Based Study

Association of traditional and novel measures of central obesity with cognitive performance in older multi‐ethnic Asians with type 2 diabetes

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