Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects

Ghafoor, Bushra; Masthan, Shameera Shaik; Hameed, Maha; Akhtar, Hafiza Huda; Khalid, Ayesha; Ghafoor, Sana; Allah, Hassan Min; Arshad, Mohsin; Iqbal, Iqra; Iftikhar, Ahmad; Husnain, Muhammad; Anwer, Faiz

doi:10.1007/s00277-023-05345-9

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…Waldenström macroglobulinemia is a chronic B-cell lymphoproliferative disorder characterized by the overgrowth of lymphoplasmacytic cells in the bone marrow and increased IgM immunoglobulin secretion in the serum, accounting for 2% of all hematological malignancies [1,2] . Amyloidosis, monoclonal IgM deposition disease, cryoglobulinemia, and direct infiltration by lymphoplasmacytic lymphoma are the most common renal pathological manifestations [3] .…”

Section: Introductionmentioning

confidence: 99%

A Case of Waldenström Macroglobulinemia with Acute Kidney Injury as the First Manifestation and Literature Review

Xu,

Guo,

Gou

et al. 2024

PAR

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Waldenström macroglobulinemia is a rare lymphoid tumor accounting for 2% of all hematological malignancies. Renal complications are less common compared to multiple myeloma, with the most frequent renal manifestations being microproteinuria and microhematuria. This paper presents a case of Waldenström macroglobulinemia with acute kidney injury as the initial manifestation. A 75-year-old male was admitted to the Affiliated Hospital of Hebei University after elevated blood creatinine levels were detected for one day. Upon admission, his blood creatinine was 255 µmol/L, urine protein was 1+, urine erythrocytes were negative, electrophoresis showed IgM positivity in the κ-region, and a bone marrow biopsy indicated a tendency towards lymphoplasmacytic lymphoma. The patient was discharged after receiving a treatment regimen of prednisone acetate, thalidomide, and cyclophosphamide, and continued oral medication outside the hospital. The patient returned two weeks later due to diarrhea and was found to have a blood creatinine level of 985 µmol/L, along with severe acidosis and hyperkalemia. The patient refused renal replacement therapy and was not followed up, resulting in a poor prognosis. Additionally, a review of the literature is provided to contextualize this case within the broader scope of existing research.

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Section: Introductionmentioning

confidence: 99%

A Case of Waldenström Macroglobulinemia with Acute Kidney Injury as the First Manifestation and Literature Review

Xu,

Guo,

Gou

et al. 2024

PAR

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Case report: Waldenstrom macroglobulinemia with systemic amyloidosis as the main manifestation

Yin,

Zhou,

et al. 2024

Front. Med.

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Systemic amyloidosis is a rare protein misfolding and deposition disorder leading to progressive organ failure. Waldenström macroglobulinemia (WM) with systemic amyloidosis as the main manifestation is even rarer. The patient in this study presented with recurrent diarrhea and had not been diagnosed in other hospitals on multiple occasions. Later, his diarrhea worsened and was accompanied by sunken edema of both lower limbs and dizziness. Renal biopsy showed deposits of PAS light-staining material in the glomeruli, interstitium, and small arteries, which stained positively with Congo red. Cardiac ultrasound showed interventricular septum thickening of 17 mm, right ventricular wall myocardial thickening of approximately 0.6 cm, and septal thickening of approximately 0.5 cm, considering myocardial amyloidosis. Electromyography showed abnormal peripheral nerve conduction. Lymphoplasmacytic cells were found in the bone marrow. Taken together, he was diagnosed with WM. He was treated with a BR (Bendamustine + Rituximab) regimen. After 6 courses, the patient’s discomfort was relieved, his weight gained 5 kg, the level of serum IgM and dFLC decreased, and cardiac and renal assessments were more relieved. The patient has been followed up for more than 1 month.

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Día 65. ¡Nos queda tanto por mirar!

García Velasco

2023

AMF

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Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects

Cited by 3 publications

References 72 publications

A Case of Waldenström Macroglobulinemia with Acute Kidney Injury as the First Manifestation and Literature Review

A Case of Waldenström Macroglobulinemia with Acute Kidney Injury as the First Manifestation and Literature Review

Case report: Waldenstrom macroglobulinemia with systemic amyloidosis as the main manifestation

Día 65. ¡Nos queda tanto por mirar!

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