Waldenström’s Macroglobulinemia, Mesangio-Capillary Glomerulonephritis, Angiitis and Myositis

Lin, Jen H.; Orofino, D.; Sherlock, Jon; Letteri, Joseph M.; Duffy, John L.

doi:10.1159/000180197

Cited by 14 publications

(6 citation statements)

References 12 publications

(14 reference statements)

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“…Monoclonal components could have various antibody activities leading to the formation of circulating immune complex [11]. Evidence for the pathogenic role is shown through a case of WM with immune complex-mediated glomerulonephritis [12]. In addition, clinical hypocomplementemia seemed to well correlate with immunofluolescent staining of C4 suggesting complement activating potential of IgM [13].…”

Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome due to Immunologically Mediated Hypocomplementic Glomerulonephritis in a Patient of Waldenström’s Macroglobulinemia

Haraguchi¹,

Tomiyoshi²,

Aoki³

et al. 2002

Nephron

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A 72-year-old man was diagnosed as having nephritic syndrome complicated by Waldenström’s macroglobulinemia (WM). A monoclonal IgM lamda protein and decreased serum complements were observed. The renal biopsy disclosed the capillary occluded by thrombi which was stained with IgG, IgA, IgM, C4, lamda light chain and slight kappa light chain in a granular pattern. Electron dense deposits were noted in the subendothelial spaces. An unusual case of WM who developed nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis is described.

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Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome due to Immunologically Mediated Hypocomplementic Glomerulonephritis in a Patient of Waldenström’s Macroglobulinemia

Haraguchi¹,

Tomiyoshi²,

Aoki³

et al. 2002

Nephron

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“…In addition to cryoglobulinemia, the monoclonal IgM from lymphoplasmacytic lymphoma (Waldenström macroglobulinemia) can also result in kidney injury characterized by a mesangiocapillary glomerulonephritis. 27 Some kidney diseases are only occasionally associated with MGRS. Previously, MPGN was only linked to infections, connective tissue disease, complement dysregulation, and malignancies but was not thought to be associated with monoclonal gammopathy.…”

Section: Introductionmentioning

confidence: 99%

Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant

Leung

Bridoux

Hutchison

et al. 2012

Blood

475

359

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Multiple myeloma is the most frequent monoclonal gammopathy to involve the kidney; however, a growing number of kidney diseases associated with other monoclonal gammopathies are being recognized. Although many histopathologic patterns exist, they are all distinguished by the monoclonal immunoglobulin (or component) deposits. The hematologic disorder in these patients is more consistent with monoclonal gammopathy of undetermined significance (MGUS) than with multiple myeloma. Unfortunately, due to the limitations of the current diagnostic schema, they are frequently diagnosed as MGUS. Because treatment is not recommended for MGUS, appropriate therapy is commonly withheld. In addition to endstage renal disease, the persistence of the monoclonal gammopathy is associated with high rates of recurrence after kidney transplantation. Preservation and restoration of kidney function are possible with successful treatment targeting the responsible clone. Achievement of hematologic complete response has been shown to prevent recurrence after kidney transplantation. There is a need for a term that properly conveys the pathologic nature of these diseases. We think the term monoclonal gammopathy of renal significance is most helpful to indicate a causal relationship between the monoclonal gammopathy and the renal damage and because the significance of the monoclonal gammopathy is no longer undetermined. (Blood. 2012;120(22):4292-4295)

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“…Nephrotic syndrome rarely develops in WMG. Amyloidosis is the main cause of it [3], but mesangiocapillary glomerulonephritis [4] and minimal change of the glomeruli [2,[5][6][7] are also responsible for it, though rarely. The present paper presents the clinical data and histopathological findings of the kidneys in a patient in whom the nonamyloidotic nephrotic syndrome devel oped during the course of WMG.…”

Section: Introductionmentioning

confidence: 99%

Nonamyloidotic Nephrotic Syndrome in Waldenström’s Macroglobulinemia

Tsuji

Ochiai²,

Taka³

et al. 1990

Nephron

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Severe nephrotic syndrome developed in an 83-year-old Japanese man with Waldenström’s macroglobulinemia. Treatment with corticoid remarkably improved the proteinuria. Autopsy disclosed no deposit of amyloid in the kidneys but a slight infiltration of atypical lymphocytes. A considerable number of glomeruli showed mesangial cell proliferation and global or segmental thickening of the basement membrane with occasional double tracks. Immunofluorescent studies revealed deposits of IgM but not IgG, IgA and C₃ along the basement membrane in most glomeruli. Electron microscopy disclosed the splitting glomerular basement membrane and scattered electron-dense deposits.

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Waldenström’s Macroglobulinemia, Mesangio-Capillary Glomerulonephritis, Angiitis and Myositis

Cited by 14 publications

References 12 publications

Nephrotic Syndrome due to Immunologically Mediated Hypocomplementic Glomerulonephritis in a Patient of Waldenström’s Macroglobulinemia

Nephrotic Syndrome due to Immunologically Mediated Hypocomplementic Glomerulonephritis in a Patient of Waldenström’s Macroglobulinemia

Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant

Nonamyloidotic Nephrotic Syndrome in Waldenström’s Macroglobulinemia

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