Walking ability to predict future cognitive decline in old adults: A scoping review

Kikkert, Lisette H J; Vuillerme, Nicolas; Campen, Jos P. van; Hortobágyi, Tibor; Lamoth, Claudine J. C.

doi:10.1016/j.arr.2016.02.001

Cited by 142 publications

(126 citation statements)

References 99 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Similarly, another review suggested that walking pace might be able to predict the occurrence of dementia among elderly population using data from seven studies (9). This rationale has been further supported by a recent review (11). Of note, all previous reviews are narrative reviews.…”

Section: Discussionmentioning

confidence: 70%

“…Walking pace, as a measure that has easier application and interpretation than other gait parameters (eg, stride length variability and stride time variability), has drawn researchers' and public health professionals' attention. Although previous qualitative systematic review suggested an inverse association between walking pace and cognitive dysfunction (9)(10)(11), the magnitude of the association and the dose-response relationship have not been systematically investigated and remain unclear. Therefore, we aimed to quantitatively summarize the up-to-date literature examining the overall association and the dose-response relationship between walking pace and the risk of cognitive decline and dementia in elderly populations.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies

Quan

Xun

Chen

et al. 2016

GERONA

View full text Add to dashboard Cite

Background: Data on the longitudinal association of walking pace with the risk of cognitive decline and dementia are inconsistent and inconclusive. Therefore, researchers conducted a meta-analysis of prospective cohort studies to quantitatively assess the association of walking pace with the risk of cognitive decline and dementia among elderly populations. Methods: Eligible studies were searched in PubMed and EMBASE through April 22, 2016. Additional information was retrieved through Google Scholar or hand review of the reference lists from the relevant studies. Prospective cohort studies were included if they reported relative risk (RR) and the corresponding 95% confidence interval (CI) of cognitive decline or dementia in relation to walking pace. Results: Seventeen studies were identified, including 10 studies reporting the RR of cognitive decline (9,949 participants and 2,547 events) and 10 presenting the RR of dementia (14,140 participants and 1,903 events). Comparing the lowest to the highest category of walking pace, the pooled RR was 1.89 (95% CI = 1.54-2.31) for cognitive decline and 1.66 (95% CI = 1.43-1.92) for dementia. With every 1 dm/s (360 m/h) decrement in walking pace, the risk of dementia was increased by 13% (RR = 1.13; 95% CI = 1.08-1.18). Conclusions: This meta-analysis provides accumulated evidence supporting that slow or decreased walking pace is significantly associated with elevated risk of cognitive decline and dementia in elderly populations.

show abstract

Section: Discussionmentioning

confidence: 70%

mentioning

confidence: 99%

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies

Quan

Xun

Chen

et al. 2016

GERONA

View full text Add to dashboard Cite

show abstract

“…However, evidence of the added value of these findings in clinical setting is still lacking. Previous researchers suggested that this could be due to the low sensitivity en specificity when gait speed is used as a single parameter[8]. Further exploration of the gait cycle may result in the detection of more useful single or clusters of gait characteristics and ensue a better understanding how gait behaves phenotypically in different age groups and in geriatric syndromes.…”

Section: Introductionmentioning

confidence: 99%

Gait characteristics under different walking conditions: Association with the presence of cognitive impairment in community-dwelling older people

et al. 2017

View full text Add to dashboard Cite

BackgroundGait characteristics measured at usual pace may allow profiling in patients with cognitive problems. The influence of age, gender, leg length, modified speed or dual tasking is unclear.MethodsCross-sectional analysis was performed on a data registry containing demographic, physical and spatial-temporal gait parameters recorded in five walking conditions with a GAITRite® electronic carpet in community-dwelling older persons with memory complaints. Four cognitive stages were studied: cognitively healthy individuals, mild cognitive impaired patients, mild dementia patients and advanced dementia patients.ResultsThe association between spatial-temporal gait characteristics and cognitive stages was the most prominent: in the entire study population using gait speed, steps per meter (translation for mean step length), swing time variability, normalised gait speed (corrected for leg length) and normalised steps per meter at all five walking conditions; in the 50-to-70 years old participants applying step width at fast pace and steps per meter at usual pace; in the 70-to-80 years old persons using gait speed and normalised gait speed at usual pace, fast pace, animal walk and counting walk or steps per meter and normalised steps per meter at all five walking conditions; in over-80 years old participants using gait speed, normalised gait speed, steps per meter and normalised steps per meter at fast pace and animal dual-task walking. Multivariable logistic regression analysis adjusted for gender predicted in two compiled models the presence of dementia or cognitive impairment with acceptable accuracy in persons with memory complaints.ConclusionGait parameters in multiple walking conditions adjusted for age, gender and leg length showed a significant association with cognitive impairment. This study suggested that multifactorial gait analysis could be more informative than using gait analysis with only one test or one variable. Using this type of gait analysis in clinical practice could facilitate screening for cognitive impairment.

show abstract

“…However, numerous longitudinal studies of gait and cognition have found that slow walking speed predicts a decline in cognition (Verghese et al, 2007; Kikkert et al, 2016). Using similar logic, future studies could evaluate whether forward neck posture predicts memory decline in subsequent years.…”

Section: Discussionmentioning

confidence: 99%

Mobility and Upright Posture Are Associated with Different Aspects of Cognition in Older Adults

Cohen

Vasavada

Wiest

et al. 2016

Front. Aging Neurosci.

View full text Add to dashboard Cite

Objectives: Aging is associated with cognitive decline, including visuomotor and memory concerns, and with motor system changes, including gait slowing and stooped posture. We investigated the associations of visuomotor performance and episodic memory with motor system characteristics in healthy older adults.Methods: Neurologically healthy older adults (N = 160, aged 50–89) completed a battery of cognitive and motor tasks. Cognitive variables were grouped by principal components analysis (PCA) into two components: visuomotor performance and verbal episodic memory. Our primary predictor variables were two aspects of motor function: timed-up-and-go (TUG) speed and neck angle. Additional predictor variables included demographic factors (age, sex and education) and indicators of physical fitness (body mass index/BMI and grip strength). All seven predictor variables were entered stepwise into a multiple regression model for each cognitive component.Results: Poor visuomotor performance was best predicted by a combination of advanced age, high BMI and slow TUG, whereas poor verbal memory performance was best predicted by a combination of advanced age, male sex, low education and acute neck angle.Conclusions: Upright posture and mobility were associated with different cognitive processes, suggesting different underlying neural mechanisms. These results provide the first evidence for a link between postural alignment and cognitive functioning in healthy older adults. Possible causal relationships are discussed.

show abstract

Walking ability to predict future cognitive decline in old adults: A scoping review

Cited by 142 publications

References 99 publications

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies

Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies

Gait characteristics under different walking conditions: Association with the presence of cognitive impairment in community-dwelling older people

Mobility and Upright Posture Are Associated with Different Aspects of Cognition in Older Adults

Contact Info

Product

Resources

About