Walking impairs cognitive performance among people with multiple sclerosis but not controls

Downer, Matthew B.; Kirkland, Megan C.; Wallack, Elizabeth M.; Ploughman, Michelle

doi:10.1016/j.humov.2016.06.010

Cited by 35 publications

(36 citation statements)

References 49 publications

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“…The effect of a motor task on concurrently performed cognitive task while walking (the DTC of cognitive performance) has previously been investigated ( 10 , 17 , 18 , 45 – 47 ). Contrary to our findings, these previous studies have shown that performing a motor task diminished cognitive performance in pwMSs compared to HCs ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

Comparing 16 Different Dual–Tasking Paradigms in Individuals With Multiple Sclerosis and Healthy Controls: Working Memory Tasks Indicate Cognitive–Motor Interference

et al. 2020

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Background: Cognitive–motor interference (CMI) is measured by dual-tasking (DT), which involves motor and cognitive tasks. There is no consensus as to whether CMI is present in multiple sclerosis (MS). Objectives: We investigated the effects of 16 DT conditions by measuring motor complexity, cognitive domain, and task difficulty. Method: In total, 40 persons with MS (pwMSs) with Expanded Disease Status Scale (EDSS) 3.2 ± 1.7 and 31 age- and sex-matched healthy controls (HCs) completed 2 single walking, 8 single cognitive, and 2 complex walking tasks and 16 cognitive–motor DT. The main outcomes were mean values of gait velocity and the percentage change from single to DT (motor DT costs, mDTCs) and mean values of cognitive task accuracy and the percentage changes (cognitive DTC, cDTC). Results: Two-way analyses of variance showed the main effect of cognitive task yielded an F ratio of F (4, 268) = 72.35, p < 0.01, for mean gait velocity, and an F ratio of F (4, 304) = 17.12, p < 0.001, for mDTC, indicating that the mean velocity was significantly lower and the mDTC significantly higher for DS_B (mean = 1.27, SD = 0.03, and mean = 13.52, SD = 1.28, respectively). The main effect of cognitive task yielded an F ratio of F (4, 116) = 84.32, p < 0.001, with the lowest average accuracy for DS_B (mean = 43.95, SD = 3.33); no effect was found for cDTC. In pwMSs, the EDSS accounted for 28% ( F = 13.65, p = 0.001) of variance in a model predicting the highest mDTC. Conclusions: Overall, among different cognitive tasks added, the Digit Span backward was the most interfering cognitive task over gait velocity and accuracy. The effect was similar independently from the motor complexity and the group. PwMSs and HCs behaved in a similar manner at all motor complexity levels and during all cognitive task.

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Section: Discussionmentioning

confidence: 99%

Comparing 16 Different Dual–Tasking Paradigms in Individuals With Multiple Sclerosis and Healthy Controls: Working Memory Tasks Indicate Cognitive–Motor Interference

et al. 2020

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“…In addition, cognitive assessment performed in a ‘sterilized’ way, might not reflect cognitive issues of patients since they might perform well in tests highly specific to a single cognitive domain, but fail in multitasking real conditions [ 95 ]. Studies have shown that walking or other motor tasks might interfere with cognitive function in MS patients [ 96 , 97 ], therefore dual-tasking measures may better reflect actual difficulties of MS patients [ 98 ].…”

Section: When To Measure and How To Deal With Findings?mentioning

confidence: 99%

The Rationale for Monitoring Cognitive Function in Multiple Sclerosis: Practical Issues for Clinicians

Bakirtzis

Ioannidis

Messinis

et al. 2018

TONEUJ

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About half of patients with multiple sclerosis exhibit cognitive impairment which negatively affects their quality of life. The assessment of cognitive function in routine clinical practice is still undervalued, although various tools have been proposed for this reason. In this article, we describe the potential benefits of implementing cognitive assessment tools in routine follow -ups of MS patients. Early detection of changes in cognitive performance may provide evidence of disease activity, could unmask depression or medication side-effects and provide suitable candidates for cognitive rehabilitation. Since apathy and cognitive deficiencies are common presenting symptoms in Progressive Multifocal Leukoencephalopathy, we discuss the utility of frequent monitoring of mental status in multiple sclerosis patients at increased risk. In addition, we propose a relevant algorithm aiming to incorporate a systematic evaluation of cognitive function in every day clinical practice in multiple sclerosis.

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“…MS has been associated with delayed recall performance and lower acquisition of verbal memory [21] and episodic short-term memory [22]. In addition, MS can also result in slow processing speed [23], which has been linked to executive function deficits [24]. …”

Section: Introductionmentioning

confidence: 99%

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

Alosaimi

AlMulhem

Moscovici

et al. 2017

Behavioural Neurology

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Introduction Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. Methods Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia. Univariate and multiple regression analyses were conducted to identify variables that are significantly associated with cognitive impairment. Results Variables that were identified to be significantly associated with cognition, p < 0.05, were education level, disease duration, and family history. Discussion Both education level and disease duration were variables identified in previous studies. We showed family history to be a significant variable, and no association was found with depression or anxiety, which is unique to our study population. Conclusions We identified several psychosocial predictors that are associated with cognition in our patient population. It was also noted that a difference exists between patient populations, highlighting the need for further studies in specific geographical regions.

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Walking impairs cognitive performance among people with multiple sclerosis but not controls

Cited by 35 publications

References 49 publications

Comparing 16 Different Dual–Tasking Paradigms in Individuals With Multiple Sclerosis and Healthy Controls: Working Memory Tasks Indicate Cognitive–Motor Interference

Comparing 16 Different Dual–Tasking Paradigms in Individuals With Multiple Sclerosis and Healthy Controls: Working Memory Tasks Indicate Cognitive–Motor Interference

The Rationale for Monitoring Cognitive Function in Multiple Sclerosis: Practical Issues for Clinicians

The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis

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