With the development of big data concept and technology, big data has an important impact on human development. This paper studies the relationship between the consumption pattern and mental health of enterprise employees under the normalization of epidemic prevention and control. Starting from the consumption structure and behavior of enterprise employees, it defines the meaning of enterprise employees’ consumption and the connotation of enterprise employees’ health psychology and analyzes the relationship between consumption behavior and consumption psychology and the elements of enterprise employees’ health psychology. Based on the change of employees’ income structure and consumption patterns, this paper speculates the relationship between employees’ consumption patterns and mental health, analyzes the correlation between employees’ consumption patterns and mental health through a questionnaire survey, and calculates the Correlation Clustering statistical results. It plays an important role in building a good enterprise staff consumption culture under the normalization of epidemic prevention and control and effectively realizes the significance of purifying the social consumption environment.