Walking while talking in patients with multiple sclerosis: The impact of specific cognitive loads

Allali, Gilles; Laidet, Magali; Assal, Frédéric; Armand, Stéphane; Lalive, Patrice H.

doi:10.1016/j.neucli.2013.10.136

Cited by 61 publications

(44 citation statements)

References 15 publications

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“…These studies have been carried out generally during short walking tasks (~10 m); however, various cognitive tasks have been utilized. Word list generation represents one of the most prominent tasks employed [ 26 – 31 , 35 , 36 ] as well as subtraction and counting tasks [ 28 , 29 , 32 – 34 ].…”

Section: Discussionmentioning

confidence: 99%

Cognitive-Motor Interference in Multiple Sclerosis: A Systematic Review of Evidence, Correlates, and Consequences

Wajda

Sosnoff

2015

BioMed Research International

104

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Individuals with multiple sclerosis (MS) regularly exhibit deficits in motor and cognitive function. Recent evidence suggests that these impairments are compounded when motor and cognitive task are performed simultaneously such as walking while talking. The changes incurred during simultaneous performance of motor and cognitive tasks are a result of cognitive-motor interference (CMI) and operationalized as dual task costs (DTC). Recently in MS, research has been conducted to understand and analyze the impact of CMI. The purpose of this paper was to review the current literature related to the evidence, correlates, and consequences of CMI in MS. Relevant literature was collected from the results of a PubMed search for terms including “Cognitive-motor interference” or “Cognitive-motor interaction” or “Dual task” and “multiple sclerosis.” Overall, 20 papers were included for review which focused on CMI during balance and walking tasks. The finding that there is a lack of evidence pertaining to changes in the cognitive domain as well as to the specific consequences of CMI in MS was noted. Future work should aim to fill these gaps and ultimately investigate the usefulness of targeted interventions in reducing the deleterious effects of CMI in individuals with MS.

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Section: Discussionmentioning

confidence: 99%

Cognitive-Motor Interference in Multiple Sclerosis: A Systematic Review of Evidence, Correlates, and Consequences

Wajda

Sosnoff

2015

BioMed Research International

104

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“…After three familiarization trials, each participant performed five 10 m walking trials: one consisted in walking normally (single-task) and four consisted in walking while performing one of the four interfering cognitive tasks simultaneously (dual-task). Our dual-task paradigm proposed four different cognitive tasks of various attention load (Allali, Laidet, Assal, Armand, & Lalive, 2014), randomly performed: counting forward (CF, serial 1+1), counting backward (CB, serial 100-1), semantic verbal fluency of words in the category of "Animals" (FAn) and phonemic verbal fluency with words beginning with the "P" letter (FP). Our protocol consisted of only one trial per situation due to the increased fatigability of post-stroke participants.…”

Section: Methodsmentioning

confidence: 99%

“…working memory (CB), and executive function (FAn and FP) resources, respectively (Allali et al, 2014;Plummer-D'Amato et al, 2010). Consistently with previous literature, we found a reduced cognitive capacity in stroke survivors during the walking dual-tasks compared to the cognitive task performed in the sitting position.…”

Section: 2dual-tasking Modulates the Dynamic Stability Strategy Ofmentioning

confidence: 99%

Cognitive-motor dual-task interference modulates mediolateral dynamic stability during gait in post-stroke individuals

Tisserand

Armand

Allali

et al. 2018

Human Movement Science

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Gait asymmetry and dynamic balance impairments observed in post-stroke individuals increase their risk of fall. Moreover, walking while performing a cognitive task (i.e. dual-task) disturbs the control of balance in post-stroke individuals. Here we investigated the mediolateral dynamic stability in twenty-two community-dwelling participants (12 post-strokes and 10 healthy controls) while walking in single-task (normal gait) and four different dual-tasks (cognitive-motor interference). Positions of the extrapolated center of mass and mediolateral widths of both margin of stability and base of support were extracted from 35 marker trajectories. Post-stroke participants presented larger margin of stability and base of support than controls during single-task (both p < 0.01), with a larger margin of stability on the non-paretic side than on the paretic side at ipsilateral foot-strike (p < 0.05). No significant effect of the dual-task was found between groups. In post-stroke participants, dual-task induced slight modification of the mediolateral stability strategy, as the margin of stability was not different between the two limbs at foot-strike, and significantly reduced the performance in every cognitive task. Post-stroke participants increased their dynamic stability in the frontal plane in single-task by extending their base of support and mainly relying on their non-paretic limb. Under cognitive-motor interference (dual-task), post-stroke participants prioritized dynamic stability over cognitive performance to ensure a safe locomotion. Thus, rehabilitation programs should consider both dynamic balance and dual-task training, even at a chronic delay following stroke, to reduce the risk of fall in post-stroke individuals.

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“…Moreover, at long term, gait disorders are not exclusively related to motor neurological disorders caused by demyelination [31]. Patients with MS are more prone to osteoarthritis [31] and there is a clear interaction between cognitive and gait disorders [32,33]. Certain studies attempted to find correlations with the EDSS [21,30] but this is also difficult because the EDSS score reflects both dimensions (evaluation and progression).…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis and Clinical Gait Analysis before and after Fampridine: A Systematic Review

Lecat¹,

Decavel²,

Magnin³

et al. 2017

Eur Neurol

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Background: Gait impairment is one of the most disabling symptoms in people with multiple sclerosis (PwMS). Fampridine, has demonstrated a positive effect on gait speed in PwMS after 14 days of treatment but the long-term effects have not yet been demonstrated. This study reviews the long-term effects of fampridine on gait in PwMS. Summary: This systematic review was conducted according to the PRIS-MA statement. Studies were considered long term if treatment exceeded 28 days. From the 498 studies identified, 18 (2,200 patients) fulfilled all eligibility criteria. Only 3 studies followed-up patients for >1 year and one of these showed a non-significant improvement in the gait speed. Key Messages: Fampridine seems to be beneficial at improving gait speed in PwMS in the long term. Further long-term studies are needed on related gait and functional parameters.

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Walking while talking in patients with multiple sclerosis: The impact of specific cognitive loads

Cited by 61 publications

References 15 publications

Cognitive-Motor Interference in Multiple Sclerosis: A Systematic Review of Evidence, Correlates, and Consequences

Cognitive-Motor Interference in Multiple Sclerosis: A Systematic Review of Evidence, Correlates, and Consequences

Cognitive-motor dual-task interference modulates mediolateral dynamic stability during gait in post-stroke individuals

Multiple Sclerosis and Clinical Gait Analysis before and after Fampridine: A Systematic Review

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