Wall characteristics and mechanisms of ischaemic stroke in patients with atherosclerotic middle cerebral artery stenosis: a high-resolution MRI study

Zhao, Dongyan; Deng, Gang; Xie, Bo; Gao, Bo; Peng, Cheng-Yu; Nie, Fang; Yang, Ming; Ju, Shenghong; Teng, Gao‐Jun

doi:10.1179/1743132815y.0000000088

Cited by 20 publications

(15 citation statements)

References 29 publications

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“…Previous studies have found that contrast enhancement of atherosclerotic MCA plaques might serve as a marker of plaques’ stability using HR-MRI (Qiao et al, 2014; Teng et al, 2016). Other researches demonstrated that symptomatic patients had larger vessel area, wall area, plaque burden, and remodeling ratio in stenotic MCA than that in asymptomatic patients, and a higher prevalence of positive PR was found in symptomatic patients (Xu et al, 2010; Chung et al, 2012; Zhu et al, 2013; Zhao et al, 2015, 2016). Our findings were consistent with these studies.…”

Section: Discussionmentioning

confidence: 92%

A High-Resolution MRI Study of Relationship between Remodeling Patterns and Ischemic Stroke in Patients with Atherosclerotic Middle Cerebral Artery Stenosis

Zhang

Chen

et al. 2017

Front. Aging Neurosci.

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Purpose: Recently, high-resolution magnetic resonance imaging (HR-MRI) has been used to depict the wall characteristics of the intracranial arteries. The aim of this study was to explain the relationship between the remodeling patterns and acute ischemic stroke in patients with atherosclerotic middle cerebral artery (MCA) stenosis using HR-MRI.Materials and Methods: From August 2015 to May 2016, we prospectively screened 33 consecutive patients with unilateral MCA stenosis using time-to-flight MR angiography, including 15 patients with symptomatic MCA stenosis and 18 patients with asymptomatic MCA stenosis. Among them, 14 patients were diagnosed as positive remodeling (PR) and 19 as negative remodeling or non-remodeling. The cross-sectional images of the stenotic MCA wall on HR-MRI including T1WI, T2WI, and PDWI were compared between the symptomatic group and the asymptomatic group as well as the PR group and the non-PR group, based on the vessel area, lumen area, wall area, plaque area, degree of stenosis, remodeling index, and NIHSS score.Results: The symptomatic group had larger wall area (P = 0.040), plaque area (P<0.001), degree of stenosis (P = 0.038), remodeling index (P < 0.001), and NIHSS score (P = 0.003) as well as smaller lumen area (P = 0.001) than the asymptomatic group. In addition, more PR patients were observed in symptomatic group. The PR group had larger plaque area (P = 0.014) and NIHSS score (P = 0.037) than the non-PR group. Demographic and clinical characteristics between the symptomatic group and the asymptomatic group, the PR group and the non-PR group showed no statistical difference.Conclusion: The current study suggests that the HR-MRI has emerged as a promising tool to detect the characteristics of intracranial arteries wall and reveal the relationship between remodeling patterns and ischemic stroke. The PR is an unsafe remodeling way and is prone to cause acute ischemic stroke.

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Section: Discussionmentioning

confidence: 92%

A High-Resolution MRI Study of Relationship between Remodeling Patterns and Ischemic Stroke in Patients with Atherosclerotic Middle Cerebral Artery Stenosis

Zhang

Chen

et al. 2017

Front. Aging Neurosci.

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“…Moreover, we encourage further studies to investigate spontaneous HT on the basis that IS patients do not receive any therapy. To determine the specific mechanisms underlying spontaneous HT, studies of the structural changes that occur in different infarction patterns 25 are needed.…”

Section: Discussionmentioning

confidence: 99%

Frequency and risk factors of spontaneous hemorrhagic transformation following ischemic stroke on the initial brain CT or MRI: data from the China National Stroke Registry (CNSR)

Chen

Wang

Zhao

et al. 2016

Neurological Research

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“…10–12 Nevertheless, few studies have focused on unraveling the differences in plaque features among stroke subtypes, such as A-to-A embolism, which may help to understand the vascular pathophysiology associated with this type of ischemic stroke and predict stroke recurrence. 13, 14…”

Section: Introductionmentioning

confidence: 99%

Hyperintense Plaque on Intracranial Vessel Wall Magnetic Resonance Imaging as a Predictor of Artery-to-Artery Embolic Infarction

Wu¹,

Song²,

Ma³

et al. 2018

Stroke

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Wall characteristics and mechanisms of ischaemic stroke in patients with atherosclerotic middle cerebral artery stenosis: a high-resolution MRI study

Abstract: PR or irregular surface plaques were associated with artery-to-artery embolism. Superior location of plaques was associated with PAI. HR-MRI provides insights into intracranial atherosclerosis in vivo, predictive of infarction patterns.

Cited by 20 publications

References 29 publications

A High-Resolution MRI Study of Relationship between Remodeling Patterns and Ischemic Stroke in Patients with Atherosclerotic Middle Cerebral Artery Stenosis

A High-Resolution MRI Study of Relationship between Remodeling Patterns and Ischemic Stroke in Patients with Atherosclerotic Middle Cerebral Artery Stenosis

Frequency and risk factors of spontaneous hemorrhagic transformation following ischemic stroke on the initial brain CT or MRI: data from the China National Stroke Registry (CNSR)

Hyperintense Plaque on Intracranial Vessel Wall Magnetic Resonance Imaging as a Predictor of Artery-to-Artery Embolic Infarction

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