Wall shear stress on LDL accumulation in human RCAs

Soulis, Johannes V.; Fytanidis, Dimitrios K.; Papaioannou, Vassilios; Giannoglou, George D.

doi:10.1016/j.medengphy.2010.05.011

Cited by 42 publications

(32 citation statements)

References 19 publications

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“…Concentration of low-density lipoprotein (LDL) across the arterial luminal surface is a critical step in AS development [5][6][7]. Flow field changes significantly affect the accumulation and distribution of LDL, and regional variations in flow field may thus contribute to the localization of AS [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish

Xie

Tan

Wei

et al. 2013

J. R. Soc. Interface.

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Atherosclerosis (AS) commonly occurs in the regions of the arterial tree with haemodynamic peculiarities, including local flow field disturbances, and formation of swirling flow and vortices. The aim of our study was to confirm low-density lipoprotein (LDL) concentration polarization in the vascular system in vitro and in vivo, and investigate the effects of LDL concentration polarization and flow field alterations on atherosclerotic localization. Red fluorescent LDL was injected into optically transparent Flk1: GFP zebrafish embryos, and the LDL distribution in the vascular lumen was investigated in vivo using laser scanning confocal microscopy. LDL concentration at the vascular luminal surface was found to be higher than that in the bulk. The flow field conditions in blood vessel segments were simulated and measured, and obvious flow field disturbances were found in the regions of vascular geometry change. The LDL concentration at the luminal surface of bifurcation was significantly higher than that in the straight segment, possibly owing to the atherogenic effect of disturbed flow. Additionally, a stenosis model of rabbit carotid arteries was generated. Atherosclerotic plaques were found to have occurred in the stenosis group and were more severe in the stenosis group on a high-fat diet. Our findings provide the first ever definite proof that LDL concentration polarization occurs in the vascular system in vivo. Both lipoprotein concentration polarization and flow field changes are involved in the infiltration/accumulation of atherogenic lipids within the location of arterial luminal surface and promote the development of AS.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish

Xie

Tan

Wei

et al. 2013

J. R. Soc. Interface.

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“…between the mass flow transported through the vessel wall by infiltration flow (¼C w V w ) and amount of flow which goes back to the bulk flow (¼D(∂C/∂n)) [22].…”

Section: Mass Transfer In the Straight Arterial Segmentsmentioning

confidence: 99%

Computational modeling of geometry effects on the IDL surface concentration in the presence of non-uniform magnetic field – links to atherosclerosis

Aminfar

Mohammadpourfard

Khajeh

2016

Journal of Magnetism and Magnetic Materials

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“…The surface concentration of LDL was increased up to 20% distal to a stenosis, in which a recirculation zone was formed and ESS was low, compared with the LDL concentration within the blood. Although the degree of increase in luminal surface LDL concentration is mostly affected by the blood velocity near the vessel wall [46,47], LDL is elevated at locations wherever ESS is low in the arterial system [43][44][45][46][47]. These focally increased concentrations of LDL molecules exacerbate the local atherogenic process.…”

Section: Ldl Cholesterol and Low Endothelial Shear Stressmentioning

confidence: 99%

The effect of statins on high-risk atherosclerotic plaque associated with low endothelial shear stress

Takahashi

Papafaklis²,

Sakamoto³

et al. 2011

Current Opinion in Lipidology

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The relationship between low ESS and statins has not been fully investigated, but the available data underscore the vasculoprotective effect of statins. Understanding the mechanisms whereby statins reduce the atherogenic and inflammatory phenotype resulting from a low ESS environment would provide new insights to design strategies to prevent regional formation of high-risk, inflamed plaques likely to rupture and cause an adverse clinical event.

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Wall shear stress on LDL accumulation in human RCAs

Cited by 42 publications

References 19 publications

In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish

In vitro and in vivo investigations on the effects of low-density lipoprotein concentration polarization and haemodynamics on atherosclerotic localization in rabbit and zebrafish

Computational modeling of geometry effects on the IDL surface concentration in the presence of non-uniform magnetic field – links to atherosclerosis

The effect of statins on high-risk atherosclerotic plaque associated with low endothelial shear stress

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