Wallerian degeneration: evaluation with MR imaging.

Kühn, Matthew J.; Johnson, Karen A.; Davis, K R

doi:10.1148/radiology.168.1.3380957

Cited by 98 publications

(47 citation statements)

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“…The pathological process in WD has been characterized using conventional MR (45). Changes from 20 days to 2 -4 months appear as a low signal on T2 images, as tracts become hydrophobic due to myelin and protein breakdown.…”

Section: Discussionmentioning

confidence: 99%

Demonstration of Differentially Degenerated Corpus Callosam in Patients With Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship

et al. 2015

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Background: Traumatic brain injury (TBI) has been shown to predominantly affect the corpus callosum (CC). In light of the anatomical organization of cortico-callosal connections, we hypothesized that injury to the different cortical lobes may specifically affect their corresponding subdivisional fibers in the CC. Objectives: The aim of this study was to investigate lesion-related Wallerian degeneration across the subdivisions of the CC in patients with moderate TBI. Patients and Methods: Diffusion tensor tractography (DTT) was performed between 14 days and 6 months after trauma in 18 patients with moderate TBI, and 11 age-and gender-matched healthy control subjects. Based on conventional magnetic resonance imaging findings, patients were classified into 3 groups: A) frontal lobe injury; B) occipito-temporal lobe injury; and C) fronto-parieto-temporal lobe injury. The CC was divided into seven subdivisions based on Witelson's classifications. Fractional anisotropy (FA) and mean diffusivity (MD) values from the seven segments were compared among patient groups and controls. Results: Compared to controls, Group A showed significantly reduced FA in the rostrum, genu, splenium, and CC. Group B showed significantly reduced FA in the isthmus and whole CC relative to that in the controls. In Group C, FA significantly decreased across the entire CC compared to that in the controls. Conclusions: In our study, subdivisional fibers of the CC showed secondary microstructural changes resulting from primary injury in the corresponding cortical areas. We conclude that DTT-derived measures may act as an indicator of ongoing Wallerian degeneration. By extension, this study may improve our understanding of variable neuropsychological outcomes in clinically similar patients with TBI.

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Section: Discussionmentioning

confidence: 99%

Demonstration of Differentially Degenerated Corpus Callosam in Patients With Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship

et al. 2015

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“…30,31 This bright signal intensity on T2-weighted images is said to persist and can be seen as late as 29 years after brain infarction. 29,30 Although the diagnostic problem of PHI has been recognized, 34 the studies reporting the frequency and radiological and clinical correlates of PHI are still quite few. In a Japanese study, 35 bilateral PHI was found in 29 of 211 (12.9%) poststroke patients.…”

Section: Discussionmentioning

confidence: 99%

MRI Pontine Hyperintensity After Supratentorial Ischemic Stroke Relates to Poor Clinical Outcome

Mäntylä

Pohjasvaara²,

Vataja³

et al. 2000

Stroke

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Background and Purpose-MRI studies in patients with atherosclerosis often reveal ill-defined hyperintensity in the pons on T2-weighted images. This pontine hyperintensity (PHI) does not fulfill the criteria of a brain infarct, and its clinical relevance is not established. We examined the frequency, as well as the radiological and clinical correlates, of PHI in poststroke patients. Methods-Three hundred nineteen patients were studied 3 months after supratentorial ischemic stroke with the use of 1.0-T MRI. Brain infarcts, atrophy, white matter hyperintensities, and PHI were registered. The clinical outcome was assessed 3 and 15 months after the stroke. Results-Of the patients, 152 (47.6%) had PHI. The risk factors for stroke did not differ in patients without or with PHI.PHI was related to a higher frequency (Pϭ0.002) and larger volume (PϽ0.001) of supratentorial brain infarcts, to parietal (Pϭ0.020) and temporal (Pϭ0.002) atrophy, to central atrophy (PՅ0.040), and to white matter hyperintensity grade (PϽ0.001). Brain infarcts that affected the corpus striatum (putamen, caudate, and pallidum) (PՅ0.011) or pyramidal tract (PϽ0.001) were more frequent in patients with PHI. The 3-and 15-month outcomes were worse in patients with PHI (PՅ0.004). The total volume of brain infarcts (OR 1.22), mean atrophy (OR 3.59), and PHI (OR 3.76) were independent correlates of a poor 15-month outcome. Conclusions-PHI after supratentorial ischemic stroke deserves attention because it relates to poor clinical outcome.(Stroke. 2000;31:695-700.)

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“…Paraplegia 32 (1994) [9][10][11][12][13][14][15][16][17][18] differentiated by T2 values. A more detailed investigation of this method will be neces sary in the future.…”

Section: Referencesmentioning

confidence: 99%

Monitoring the evolution of intramedullary lesions in cervical spinal cord injury. Qualitative and quantitative analysis with sequential MR imaging

Taneichi¹,

Abumi²,

Kaneda³

et al. 1994

Spinal Cord

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The evolution of intramedullary lesions following an acute spinal cord injury was monitored with sequential magnetic resonance (MR) imaging. Seven patients who had sustained cervical spinal cord injuries were followed up from the acute to the chronic phase of the cord injury. MR images were evaluated not only qualitatively but also quantitatively. All intramedullary lesions were quantita tively analysed by T2 values. In the qualitative analysis, the regions with hyperintensity on T2-weighted images and isointensity on T1-weighted images were consistent with the region of simple oedema or gliosis. The former gradually disappeared after the acute phase, whereas the latter remained until the chronic phase. The regions with hyperintensity on T2-weighted images and hypointensity on Tl-weighted images may represent cysts filled with necrotic tissue or clear fluid, or necrosis. The evolution of these lesions was also able to be monitored quantitatively by T2 values.

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Wallerian degeneration: evaluation with MR imaging.

Cited by 98 publications

References 0 publications

Demonstration of Differentially Degenerated Corpus Callosam in Patients With Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship

Demonstration of Differentially Degenerated Corpus Callosam in Patients With Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship

MRI Pontine Hyperintensity After Supratentorial Ischemic Stroke Relates to Poor Clinical Outcome

Monitoring the evolution of intramedullary lesions in cervical spinal cord injury. Qualitative and quantitative analysis with sequential MR imaging

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