2024
DOI: 10.1002/jsfa.13907
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Walnut peptide relieves hypertension and associated kidney and heart injury by regulating the renin–angiotensin–aldosterone system and intestinal microbiota

Shupeng Chen,
Pengtao Huan,
Ting Ma
et al.

Abstract: BACKGROUNDHypertension is a chronic disease with high morbidity and mortality. Previously, we screened a walnut meal peptide FDWLR (PEP) with significant angiotensin‐converting enzyme inhibitory activity. The present study further investigated the anti‐hypertensive effects of PEP in vivo using spontaneously hypertensive rats.RESULTSThe results indicated that PEP reduced blood pressure and the indices in the renin–angiotensin–aldosterone system (RAAS) including angiotensin‐converting enzyme (ACE) (decreased by … Show more

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