Wampetin, a furocoumarin from Clausena wampi

Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: Anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects

“…The C 13 -and C 18 -carbazole alkaloids, simple and prenylated coumarins, furocoumarins, amines and novel amides were isolated from different parts of the plant, indicating similarities in their constituents (Khan et al, 1983;Yang et al, 1988;Lakshmi et al, 1989;Lin, 1989;Li and McChesney, 1990;Li et al, 1991;Kumar et al, 1995;Liu et al, 1996;Adebajo et al, 1998;Ito et al, 1998;Wu and Li, 1999;Zhao et al, 2004). Some pharmacological effects such as anti-lipid peroxidation, cerebral protective, hepatoprotective, hypoglycaemic, anticonvulsant, cardiovascular and antitumour have been reported for some coumarins and amides, such as clausenamide and clausenacoumarine, isolated from the leaf (Shen et al, 1989;Li et al, 1991;Liu et al, 1991Liu et al, , 1996.…”

Antioxidant and anticancer activities of 8-hydroxypsoralen isolated from wampee [Clausena lansium (Lour.) Skeels] peel

“…The pulp can be added to fruit cups or made into pie, jam or jelly. Previous chemical studies on C. lansium included the characterisation of coumarin (Khan, Naqvi, & Ishratullah, 1983) from the bark, triterpene alcohol from aerial parts (Lakshmi, Raj, & Kapil, 1989), amide derivatives from the seeds (Lin, 1989), cyclic amides form the leaves (He, Yong, & Liang, 1988) and volatile compounds from leaf, fruit and seed (Chokeprasert, Charles, Sue, & Huang, 2007). The bioactivities from wampee are mainly focused on its leaf, stem and seed which include hepatoprotective activity (Liu, Li, Chen, & Wei, 1996), hypoglycemic (Ma, Wu, & Huang, 2008), antifungal and antiviral activities (Ng, Lam, & Fong, 2003), antiplatelet (Fan, Han, Kang, & Park, 2001), anti-inflammatory, antidiabetic and antioxidant activities (Adebajo et al, 2008).…”

New coumarins from Clausena lansium twigs

“…9 These results implied that this molecule is a 5,7-oxygenated coumarin nucleus. Moreover, the 1 H NMR spectrum also showed signals of -OCH 2 -CH=C-unit at The remaining seven known coumarins included xanthotoxol (1), 7 imperatorin (2), 11 heraclenin (3), 12 heraclenol (4), 13 wampetin (6), 14 indicolactonediol (7), 15 and isoscopoletin (8) 16 were determined by the 1D and 2D NMR spectral data and comparison with their reported physical and spectroscopic data. In addition, the complete assignments of 1 H and 13 C NMR of indicolactonediol (7) are also reported herein for the first time (Table 1).…”